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Tampa Bay Rays vs Cleveland Guardians Prediction 8/25/2025 Today’s MLB Picks

Aug 24, 2025; Tampa, Florida, USA; Tampa Bay Rays third baseman Junior Caminero (13) looks on against the St. Louis Cardinals in the third inning at George M. Steinbrenner Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

Aug 24, 2025; Tampa, Florida, USA; Tampa Bay Rays third baseman Junior Caminero (13) looks on against the St. Louis Cardinals in the third inning at George M. Steinbrenner Field. Mandatory Credit: Nathan Ray Seebeck-Imagn Images

MATCHUP Tampa Bay Rays Cleveland Guardians
Team Records 63-67 64-65
Where Progressive Field, Cleveland, Ohio
When Monday, August 25, 2025
Time 06:40 PM EDT
TV FS1

The Tampa Bay Rays and the Cleveland Guardians meet Monday in MLB action from Progressive Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Tampa Bay Rays vs. Cleveland Guardians prediction.

Starting Pitching Matchup

The Tampa Bay Rays will send out Ian Seymour for the start here and Seymour is 1-0 with a 3.86 ERA and 26 strikeouts this season. This will be Seymour’s first career start against the Guardians. Tanner Bibee will get the nod for the Guardians here and is 9-9 with a 4.62 ERA and 129 strikeouts this season. In his career, Bibee is 1-1 with a 3.46 ERA and 14 strikeouts against the Rays.

Tampa Bay Rays Recap

The Tampa Bay Rays come into this game looking to add on to their win over the St. Louis Cardinals from Sunday’s series finale to sit at 63-67 this season. After this series, the Rays will head on the road for a series against the Washington Nationals.

Rays Win Back-To-Back Games

Jonathan Aranda has 113 hits with 22 doubles, 12 home runs and 54 RBIs. Brandon Lowe has 107 hits with 25 homers and 63 RBIs as well while Junior Caminero has 124 hits with 21 doubles, a team-high 37 home runs and 91 RBIs. Yandy Diaz has 135 hits with 22 doubles, 21 homers and 73 RBIs.

Why the Tampa Bay Rays will win

Tampa Bay Rays Player Prop Facts

Cleveland Guardians Recap

The Cleveland Guardians come into this game looking to bounce back from their 5-0 loss at the hands of the Rangers in Sunday’s series finale to drop to 64-65 this season. After this series, the Guardians will take on the Seattle Mariners in a series at home.

Guardians Lose Five In A Row

Steven Kwan has 134 hits as part of a .275 batting average and 10 home runs, 22 doubles and 40 RBIs. Kyle Manzardo has 83 hits with 14 doubles, 2 triples, 21 home runs and 55 RBIs as well this year. Gabriel Arias has 20 doubles but also 121 strikeouts and Manzardo has 105 strikeouts so far this season. Arias has also added 9 home runs and 45 RBIs and Jose Ramirez has chipped in 26 home runs and 68 RBIs with 36 stolen bases as well. Carlos Santana has also added 89 hits with 11 home runs and 52 RBIs as well this season.

Why the Cleveland Guardians will win

Cleveland Guardians Player Prop Facts

Total Runs Facts

Tampa Bay Rays vs. Cleveland Guardians Prediction

I’m going to back the Rays here. The Guardians continue to struggle, and it’s just hard to feel good about the direction that the Guardians are headed in in their current form. Cleveland continues to look like the Guardians that struggled their way through the earlier part of the season, and the offense has fallen off of a cliff in recent games. The Rays aren’t going to be part of the postseason I’m guessing, but they’re still competitive and Bibee’s been giving up runs for Cleveland left and right this season. I’ll side with the Rays here.

Chris Ruffolo's Pick: Tampa Bay +115

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