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Tampa Bay Rays vs Cleveland Guardians Prediction 4/29/2026 Today’s MLB Picks

Apr 1, 2026; Milwaukee, Wisconsin, USA; Tampa Bay Rays pitcher Drew Rasmussen (57) delivers a pitch against the Milwaukee Brewers in the first inning at American Family Field. Mandatory Credit: Michael McLoone-Imagn Images

Apr 1, 2026; Milwaukee, Wisconsin, USA; Tampa Bay Rays pitcher Drew Rasmussen (57) delivers a pitch against the Milwaukee Brewers in the first inning at American Family Field. Mandatory Credit: Michael McLoone-Imagn Images

MATCHUP Tampa Bay Rays Cleveland Guardians
Team Records 18-11 15-16
Spread -1.5 167 +1.5 -205
Moneyline +100 -120
Total Over 6.5 (-112) Under 6.5 (-108)
Where Progressive Field, Cleveland, Ohio
When Wednesday, April 29, 2026
Time 01:10 PM EDT
TV MLB.TV

In this article, we will formulate a Rays vs Guardians Prediction for this MLB matchup on Wednesday, April 29th in the third game of this series. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Preview

The Cleveland Guardians have a 15-16 record this season and are sitting in the second place of the AL Central. They have a 8-7 home record and are coming off a 0-1 home loss against the Rays. Their previous three games were a 2-3 home loss against the Rays, a 2-4 road loss and a 3-5 road loss against the Blue Jays.

The Guardians have a .227 batting average this season, .314 OBP and .373 Slugging percentage. Cleveland’s pitching staff has a 3.93 ERA and 1.25 WHIP. Angel Martinez is the team’s best hitter with a .278 batting average. Brayan Rocchio leads the team in RBI with 17, and Jose Ramirez adds a team‑high 6 home runs.

Gavin Williams (R) is the projected starting pitcher for the Guardians, and he has a 4-1 record, 3.28 ERA and 1.09 WHIP.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 18-11 record this season and are sitting in the second place of the AL East. They have a 10-7 away record and are coming off a 1-0 road win against the Guardians. Their previous three games were a 3-2 road win against the Guardians, a 4-2 home win and a 6-1 home win against the Twins.

The Rays have a .253 batting average this season, .330 OBP and .385 Slugging percentage. Tampa Bay’s pitching staff has a 4.13 ERA and 1.23 WHIP. Yandy Diaz is the team’s best hitter with a .324 batting average. Jonathan Aranda leads the team in RBI with 25, and Junior Caminero adds a team‑high 8 home runs.

Drew Rasmussen (R) is the projected starting pitcher for the Rays, and he has a 2-0 record, 2.45 ERA and 0.74 WHIP.

Tampa Bay Rays @ Cleveland Guardians Betting Trends: April 29, 2026

Why the Cleveland Guardians will win

Why the Tampa Bay Rays will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Tampa Bay Rays Player Prop Facts

Matchup/League Facts

Rays vs Guardians Prediction

The Guardians are 7-4 in their last 11 meetings against the Rays and are 4-3 in their last 7 meetings in Cleveland. Under is 8-2-1 in their last 11 meetings.  

In this Rays vs Guardians Prediction, the Guardians are coming as -120 home favorites. Rays won yesterday in a game that had only one total run and today’s starting pitchers have both been excellent, with a combined 5.73 ERA and extremely low WHIP. They have also fared extremely well in their start against the opposing team last season and both teams are a perfect 7-0 to the under in their last 7 games combined. Keep it simple and take the under 7 in this one.

Nikos Lagouretos's Pick: Under 7

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