Tampa Bay Rays vs Chicago Cubs Prediction 9/13/2025 Today’s MLB Picks

In this article, we will formulate a Rays vs Cubs Prediction for this MLB game on Saturday, September 13th at the Wrigley Field the second game of this series, with the Cubs having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have an 84-63 record this season and are sitting on the second place of the NL Central. The Cubs have a 45-28 home record and are 66-70 in over/under. They are coming off a 6-4 home victory over the Rays, and have three straight wins. Under is 6-3 in their last 9 games and are playing the Pirates and the Reds next.

The Cubs have a .249 batting average this season, .320 OBP and .426 Slugging percentage. Chicago’s pitching staff has a 3.86 ERA and 1.19 WHIP. Nico Hoerner leads the Cubs with 158 hits, and he is the team’s best hitter with a .296 batting average. Seiya Suzuki leads the team in RBI, with 91, adding a team-high 28 home runs.

Colin Rea (R) is the projected starting pitcher for the Cubs, and he has a 10-6 record, 4.20 ERA and 1.31 WHIP.

Tampa Bay Rays Preview

The Tampa Bay Rays have a 72-75 record this season and are sitting on the 4th place of the AL East. The Rays have a 34-39 road record and are 64-74 in over/under. They are coming off a 4-6 road defeat by the Cubs, and are 1-6 in their last 7 games. Over is 8-4 in their last 12 games and are playing the Red Sox and the Blue Jays next.

The Rays have a .251 batting average this season, .313 OBP and .402 slugging percentage. Tampa’s pitching staff has a 3.90 ERA and 1.21 WHIP.  Yandy Diaz leads the Rays with 157 hits, and he is the team’s best hitter with .290 batting average. Junior Caminero leads the team in RBI, with 106 and in home runs, with 42.

Drew Rasmussen (R) is the projected starting pitcher for the Rays, and he has a 10-5 record, 2.64 ERA and 0.98 WHIP.

Tampa Bay Rays @ the Chicago Cubs Betting Trends: September 13, 2025

• Probable Starting Pitcher: Colin Rea      Record this season: 10-6      ERA: 4.20
• Home Record: 5-3
• Last 5 against Rays: 1-0

Why the Chicago Cubs will win

• The Rays have lost 14 of their last 15 road games against teams that held a winning record.
• The Cubs have won eight of their last nine games against American League opponents that held a losing record.
• The Rays have failed to cover the run line in each of their last seven games.
• The Cubs have covered the run line in seven of their last eight home games against the Rays.
• The Cubs have led after 3 innings in each of their last eight home games against AL East opponents.
• The Rays have trailed after 5 innings in eight of their last nine games against NL Central opponents that held a winning record.

• Probable Starting Pitcher: Drew Rasmussen      Record this season: 10-5      ERA: 2.64
• Road Record: 5-0
• Last 5 against Cubs: 0-0

Why the Tampa Bay Rays will win

• The Cubs have lost eight of their last 10 games as favorites following a home win.
• The Rays have won three of their last four games as underdogs.
• The Cubs have failed to cover the run line in each of their last 10 games as favorites following a home win.
• The Rays have covered the run line in each of their last 13 Saturday day road games.
• The Rays have won the first inning in each of their last three games as underdogs.
• The Rays have led after 3 innings in three of their last four games as underdogs.
• The Rays have led after 5 innings in five of their last six games against National League opponents.

Total Runs Facts

• Nine of the Rays’ last 10 games as underdogs have gone OVER the total runs line.
• Six of the last seven games between the Rays and Cubs have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rays’ last four games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Cubs’ last six games as favorites.

Chicago Cubs Player Prop Facts

• Ian Happ has recorded a Double in each of the Cubs’ last four games as favorites against AL East opponents.
• Carson Kelly has hit at least one home run in each of his last two appearances after playing the previous day.
• Kyle Tucker has recorded at least one hit in each of his last 12 Saturday appearances.
• Nico Hoerner ranks T8th in the league in Hits (158) this season.

Tampa Bay Rays Player Prop Facts

• Brandon Lowe has recorded a Double in three of his last four appearances against opponents that held a winning record.
• Brandon Lowe has hit a home run in two of his last three appearances against NL opponents.
• Drew Rasmussen has recorded five strikeouts in three of his last four road appearances.
• Josh Lowe has recorded at least one hit in each of his last nine Saturday appearances with the Rays as underdogs.
• Drew Rasmussen has recorded a win in three of his last four appearances against NL opponents.
• Chandler Simpson ranks 2nd in the league in Steals (40) this season.

Matchup/League Facts

• The Cubs rank 1st in the league for walks allowed this season (372).
• The Cubs rank 3rd in the league for steals this season (149).
• The Rays rank 1st in the league for steals this season (181).
• The Rays are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.

Rays vs Cubs Prediction

The Rays are 3-2 in their last 5 meetings against the Cubs, but the Cubs are 3-1 in their last 4 meetings in Chicago. Under is 6-1 in their last 7 meetings.

In this Rays vs Cubs Prediction, the Cubs are coming as -120 home favorites. The Rays are putting their ace on the mound in Drew Rasmussen, who has been elite this season, and he is coming off a shutout start against the Guardians. On the flip side, Rea has 9 earned runs in his last two starts, and he is far the weakest option between the two starting pitchers. The Rays have a better bullpen, and are far better against right-handed pitching, so I like them in a bounce back spot today. Take the Tampa Bay Rays and the plus money on the road in this one.