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St. Louis Cardinals vs Washington Nationals Prediction 4/7/2026 Today’s MLB Picks

Sep 9, 2025; Seattle, Washington, USA; St. Louis Cardinals starting pitcher Matthew Liberatore (52) walks around the mound after allowing a three-run home run to left fielder Randy Arozarena (56, background) during the third inning at T-Mobile Park. Mandatory Credit: Joe Nicholson-Imagn Images

Sep 9, 2025; Seattle, Washington, USA; St. Louis Cardinals starting pitcher Matthew Liberatore (52) walks around the mound after allowing a three-run home run to left fielder Randy Arozarena (56, background) during the third inning at T-Mobile Park. Mandatory Credit: Joe Nicholson-Imagn Images

MATCHUP St. Louis Cardinals Washington Nationals
Team Records 5-5 4-6
Spread -1.5 157 +1.5 -191
Moneyline -102 -118
Total Over 7.5 (-110) Under 7.5 (-110)
Where Nationals Park, Washington, District of Columbia
When Tuesday, April 7, 2026
Time 06:45 PM EDT
TV MLB.TV

In this article, we will formulate a Cardinals vs Nationals Prediction for this MLB matchup on Tuesday, April 7th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Washington Nationals Preview

The Washington Nationals have a 4-6 record this season and are sitting in the fifth place of the NL East. They have a 1-3 home record and are coming off a 9-6 home win against the Cardinals. They dropped their previous three home games to the Dodgers by scores of 6-8, 5-10, and 6-13.

The Nationals have a .277 batting average this season, .352 OBP and .457 Slugging percentage. Washington’s pitching staff has a 6.24 ERA and 1.63 WHIP. Brady House is the team’s best hitter with a .333 batting average. CJ Abrams leads the team in RBI with 13, also adding a team-high 4 home runs.

Cade Cavalli (R) is the projected starting pitcher for the Nationals, and he has a 0-0 record, 2.79 ERA and 1.34 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 5-5 record this season and are sitting in the fourth place of the NL Central. They have a 1-3 road record and are coming off a 6-9 road loss against the Nationals. Their previous three games were a 5-3 win, a 6-11 loss, and a 0-4 loss on the road against against the Tigers.

The Cardinals have a .222 batting average this season, .305 OBP and .353 Slugging percentage. St. Louis’ pitching staff has a 5.40 ERA and 1.63 WHIP. Jordan Walker is the team’s best hitter with a .314 batting average, also leading the team in RBI with 9 and adding a team-high 3 home runs.

Matthew Liberatore (L) is the projected starting pitcher for the Cardinals, and he has a 0-0 record, 1.64 ERA and 1.18 WHIP.

St. Louis Cardinals @ Washington Nationals Betting Trends: April 7, 2026

Why the Washington Nationals will win

Why the St. Louis Cardinals will win

Total Runs Facts

Washington Nationals Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

Cardinals vs Nationals Prediction

The Cardinals are 6-2 in their last 8 meetings against the Nationals and are 3-1 in their last 4 visits in Washington.

In this Cardinals vs Nationals Prediction, both teams are coming at a pickem price. The Nationals snapped their five-game losing streak yesterday but they were involved in yet another high scoring game, as they are 5-0 to the over in their last 5 games. Both starting pitchers are coming off quality starts but both had 4+ ERA last season and both bullpens are bottom-6 in the league. Both teams also average 11 runs per game combined, so with the total set at just 7.5, I will go over that number.

Nikos Lagouretos's Pick: Over 7.5

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