St. Louis Cardinals vs Seattle Mariners Prediction 9/10/2025 Today’s MLB Picks

Chris Ruffolo

10 hours ago

Sep 6, 2025; Cumberland, Georgia, USA; Seattle Mariners outfielder Julio Rodriguez (44) celebrates with teammates in the dugout after scoring against the Atlanta Braves during the first inning at Truist Park. Mandatory Credit: Jordan Godfree-Imagn Images

St. Louis (72-74) vs Seattle (77-68)

September 10, 2025 at 09:40 PM EDT

The Line: Betting Odds: Seattle -215 — Over/Under: +7.5

The St. Louis Cardinals and the Seattle Mariners meet Wednesday in MLB action from T-Mobile Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Seattle Mariners prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Michael McGreevy for the start here and McGreevy is 6-3 with a 4.68 ERA and 43 strikeouts this season. This will be McGreevy’s first career start against the Mariners. Logan Gilbert will get the start for Seattle here and is 4-6 with a 3.61 ERA and 151 strikeouts this season. This will be Gilbert’s second career start against St. Louis.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to rebound from their 5-3 loss at the hands of Seattle on Tuesday to sit at 72-74 this season. After this series, the Cardinals will take to the road for a division series against the Milwaukee Brewers.

Cardinals Drop Back-To-Back Games

Brendan Donovan has a team-high 118 hits along with 25 doubles, 9 home runs and 45 RBIs while Lars Nootbaar has 109 hits with 13 home runs, 45 RBIs, 22 doubles and 4 stolen bases. Nolan Arenado also has 85 hits with 15 doubles, 10 home runs and 43 RBIs of his own and Victor Scott II has 81 hits with 14 doubles, a triple, 36 RBIs and a team-high 31 stolen bases. Willson Contreras has also chipped in 120 hits with 30 doubles, 20 home runs and 78 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 124 hits with 21 doubles, 17 home runs and 62 RBIs.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to add on to their win over the Cardinals from Tuesday’s matchup to sit at 77-68 this season. After this series, the Mariners will take on the Los Angeles Angels in a division series at home.

Mariners’ Win Streak Hits Four

Jorge Polanco has 106 hits including 24 home runs and 67 RBIs while Cal Raleigh has 128 hits with 19 doubles, a team-high 53 home runs and 113 RBIs. Randy Arozarena has 131 hits with 30 doubles, 26 home runs, 69 RBIs and 27 stolen bases. Julio Rodriguez also has 158 hits with 26 doubles, 4 triples, 30 home runs, 90 RBIs and 25 stolen bases. J.P Crawford has 134 hits with 20 doubles, 9 home runs and 47 RBIs.

St. Louis Cardinals @ Seattle Mariners Betting Trends: September 10, 2025

Probable Starting Pitcher: Logan Gilbert Record this season: 4-6 ERA: 3.61
Home Record: 3-2
Last 5 against Cardinals: 0-1

Why the Seattle Mariners will win

The Mariners have won 12 of their last 13 home games against teams that held a losing record.
The Cardinals have lost nine of their last 10 games against American League opponents that held a winning record.
The Cardinals have failed to cover the run line in seven of their last eight night games against AL West opponents that held a winning record.
The Mariners have covered the run line in each of their last four games.
The Mariners have led after 5 innings in five of their last six home games.
The Mariners have led after 3 innings in each of their last three games against opponents that held a losing record.

Probable Starting Pitcher: Michael McGreevy Record this season: 6-3 ERA: 4.68
Road Record: 4-0
Last 5 against Mariners: –

Why the St. Louis Cardinals will win

The Cardinals have won each of their last 11 Wednesday games as underdogs against American League opponents.
The Mariners have lost five of their last six Wednesday games as home favorites against NL Central opponents.
The Cardinals have covered the run line in each of their last 11 Wednesday games as underdogs against American League opponents.
The Mariners have failed to cover the run line in eight of their last 10 games as favorites against National League opponents following a home win.
The Cardinals have led after 5 innings in three of their last four games at T-Mobile Park.

Total Runs Facts

Six of the Mariners’ last seven games after playing the previous day have gone OVER the total runs line.
Five of the Cardinals’ last six games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Mariners’ last seven games against NL Central opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Cardinals’ last six games against American League opponents.

Seattle Mariners Player Prop Facts

Jorge Polanco has recorded a Double in five of the Mariners’ last six home games against NL opponents.
Randy Arozarena has hit a home run in three of the Mariners’ last four home games against NL opponents that held a losing record.
Logan Gilbert has recorded a win in four of his last five appearances with the Mariners as favorites against NL Central opponents.
Randy Arozarena has recorded at least one hit in each of his last 11 home appearances against former teams.
Cal Raleigh ranks 1st in the league in Home Runs (53) this season.

St. Louis Cardinals Player Prop Facts

Alec Burleson has hit a home run in three of the Cardinals’ last four road games against AL opponents that held a winning record.
Alec Burleson has recorded at least one hit in each of his last 11 road appearances against AL opponents.
Victor Scott II ranks 10th in the league in Steals (32) this season.

Matchup/League Facts

The Mariners rank 30th in the league for doubles this season (197).
The Mariners rank 29th in the league for triples this season (8).
The Cardinals rank 30th in the league for triples this season (7).
The Cardinals rank 29th in the league for strikeouts this season (1075).