| MATCHUP | St. Louis Cardinals | San Francisco Giants |
|---|---|---|
| Team Records | 72-73 | 60-85 |
| Spread | -1.5 157 | +1.5 -192 |
| Moneyline | -106 | -113 |
| Total | Over 7.5 (-116) | Under 7.5 (-104) |
| Where | Oracle Park, San Francisco, California | |
| When | Tuesday, September 8, 2026 | |
| Time | 09:45 PM EDT | |
| TV | MLB.TV | |
The St. Louis Cardinals and San Francisco Giants meet Tuesday in MLB action at Oracle Park. Here’s a St. Louis Cardinals vs San Francisco Giants Prediction. This article will include a St. Louis Cardinals vs San Francisco Giants Pick.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 72-73 this year and play the White Sox and Giants next. The St. Louis Cardinals are batting .244 on the season, with a .317 OBP and a .387 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.30 ERA and a 1.35 WHIP. Jordan Walker leads the St. Louis Cardinals with 157 hits and 100 RBI, while Alec Burleson and Ivan Herrera have combined for 293 hits and 168 RBI.
Quinn Mathews gets the ball for the St. Louis Cardinals, and he is 1-2 with a 4.38 ERA and 24 strikeouts this season. This will be Mathews’ first career game against the San Francisco Giants.
San Francisco Giants Betting Preview
The San Francisco Giants are 60-85 on the year and play the Padres and Cardinals next. The San Francisco Giants are batting .248 on the season, have a .309 OBP, and have a .407 slugging percentage. The San Francisco Giants’ pitching staff has a 4.37 ERA and a 1.36 WHIP. Rafael Devers leads the San Francisco Giants with 142 hits and 92 RBI, while Jung Hoo Lee and Willy Adames have combined for 247 hits and 104 RBI.
Landen Roupp gets the ball for the San Francisco Giants, and he is 8-13 with a 4.17 ERA and 137 strikeouts this season. This will be Roupp’s second career game against the St. Louis Cardinals.
Why the San Francisco Giants will win
- The Giants have won eight of their last nine night games against the Cardinals following a home win.
- The Cardinals have lost six of their last seven night games after going to extra innings.
- The Giants have covered the run line in five of their last six night games against teams that held a losing record.
- The Cardinals have failed to cover the run line in four of their last five games as underdogs after going to extra innings.
- The Cardinals have lost the first inning in three of their last four road games.
- The Giants have led after 5 innings in eight of their last nine games as home favorites.
Why the St. Louis Cardinals will win
- The Cardinals have won each of their last four games as underdogs against the Giants following a loss.
- The Giants have lost four of their last five games as favorites against the Cardinals following a win.
- The underdogs have covered the run line in each of the last 10 games between the Cardinals and Giants.
- The Giants have failed to cover the run line in eight of their last nine games as home favorites against NL Central opponents following a home win.
Total Runs Facts
- Eleven of the Cardinals’ last 12 road games against NL opponents have gone OVER the total runs line.
- Five of the Giants’ last six night games after playing the previous day have gone OVER the total runs line.
- There has been at least one run scored in the first inning in each of the Giants’ last 10 night games against NL opponents.
- There has been at least one run scored in the first inning in six of the Cardinals’ last seven games as road underdogs against NL opponents.
San Francisco Giants Player Prop Facts
- Landen Roupp has recorded five or more strikeouts in each of his last nine appearances with the Giants as favorites.
- Rafael Devers has recorded at least one hit in each of the Giants’ last 11 home games.
- Rafael Devers has hit a home run in each of the Giants’ last five night games against NL opponents that held a losing record.
St. Louis Cardinals Player Prop Facts
- Alec Burleson has recorded at least one hit in each of his last 13 road appearances against NL opponents that held a losing record.
- Ivan Herrera has hit a home run in two of the Cardinals’ last three games as underdogs against the Giants.
St. Louis Cardinals vs San Francisco Giants Prediction
I’m looking at the over in this spot. Mathews has a 4.38 ERA and 1.58 WHIP on the season, and he’s allowed 12 runs in his last 24.2 innings. Roupp has a 4.17 ERA and 1.29 WHIP on the season, and he’s allowed 15 earned runs in his last 31 innings. Mathews has a 5.21 ERA on the road, and Roupp has a 4.04 ERA at home. We should see some fireworks in this contest. Give me the over.