St. Louis Cardinals vs San Francisco Giants Prediction 9/23/2025 Today’s MLB Picks

Chris Ruffolo

19 hours ago

Sep 16, 2025; Phoenix, Arizona, USA; San Francisco Giants shortstop Willy Adames against the Arizona Diamondbacks at Chase Field. Mandatory Credit: Mark J. Rebilas-Imagn Images

St. Louis (77-80) vs San Francisco (77-80)

September 23, 2025 at 09:45 PM EDT

The Line: Betting Odds: San Francisco -1.5 — Over/Under: +7.5

The St. Louis Cardinals and the San Francisco Giants meet Tuesday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. San Francisco Giants prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Andre Pallante here and Pallante is 6-15 with a 5.29 ERA and 107 strikeouts this season. In his career, Pallante is 1-0 with a 5.51 ERA and 12 strikeouts against the Giants. The San Francisco Giants will trot out Logan Webb for the start here and Webb is 14-11 with a 3.27 ERA and 211 strikeouts this season. In his last five starts against the Cardinals, Webb is 3-2 with a 4.11 ERA and 29 strikeouts.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game trying to add on to their 6-5 win over the Giants from Monday’s series opener to sit at 77-80 this season. After this series, the Cardinals will head on the road for a series against the Chicago Cubs.

Cardinals Win Back-To-Back Games

Brendan Donovan has 127 hits along with 27 doubles, 10 home runs and 48 RBIs while Lars Nootbaar has 117 hits with 13 home runs, 48 RBIs, 23 doubles and 4 stolen bases. Nolan Arenado also has 91 hits with 18 doubles, 10 home runs and 49 RBIs of his own and Victor Scott II has 82 hits with 14 doubles, a triple, 37 RBIs and a team-high 33 stolen bases. Willson Contreras has also chipped in 126 hits with 31 doubles, 20 home runs and 80 RBIs of his own as well this season. Masyn Winn’s added 124 hits with 27 doubles, 9 home runs and 51 RBIs and Alec Burleson’s added 141 hits with 25 doubles, 18 home runs and 67 RBIs.

San Francisco Giants Recap

The San Francisco Giants come into this game looking to bounce back from their loss at the hands of the Cardinals in Monday’s opener to drop to 77-80 this season. After this series, the Giants will square off against the Colorado Rockies in a division series at home.

Giants Drop 8 Of Last 10

Jung Hoo Lee has 141 hits including a team-high 30 doubles along with 11 triples, 8 home runs and 52 RBIs with 10 stolen bases while Heliot Ramos has 154 hits with 24 doubles, 19 home runs and 65 RBIs. Wilmer Flores also has 16 home runs and 71 RBIs while Tyler Fitzgerald has 9 stolen bases as well on the year. Matt Chapman also has 102 hits with 21 home runs and 60 RBIs along with 21 doubles and Willy Adames has 128 hits with 21 doubles, 28 home runs and 83 RBIs of his own this season.

St. Louis Cardinals @ San Francisco Giants Betting Trends: September 23, 2025

Probable Starting Pitcher: Logan Webb Record this season: 14-11 ERA: 3.27
Home Record: 7-4
Last 5 against Cardinals: 3-2

Why the San Francisco Giants will win

The Cardinals have lost nine of their last 10 games against NL West opponents following a road win.
The Giants have won four of their last five home games following a loss.
The Cardinals have failed to cover the run line in seven of their last eight games against NL West opponents following a win.
The Giants have covered the run line in each of their last four games against NL Central opponents following a loss.
The Cardinals have trailed after 5 innings in each of their last eight Tuesday games against NL West opponents that held a losing record.
The Cardinals have trailed after 3 innings in six of their last seven road games against NL West opponents that held a losing record.
The Giants have won the first inning in each of their last four night games at Oracle Park.

Probable Starting Pitcher: Andre Pallante Record this season: 6-15 ERA: 5.29
Road Record: 2-8
Last 5 against Giants: 1-0

Why the St. Louis Cardinals will win

The Giants have lost each of their last seven games as favorites against National League opponents following a home loss.
The Cardinals have won five of their last six games as underdogs against the Giants.
The Giants have failed to cover the run line in each of their last 11 games as favorites against National League opponents following a home loss.
The Cardinals have covered the run line in each of their last eight games as underdogs against the Giants.
The Cardinals have led after 3 innings in six of their last eight games as underdogs.
The Cardinals have led after 5 innings in seven of their last eight games as underdogs.

Total Runs Facts

Eight of the Giants’ last nine home games after playing the previous day have gone OVER the total runs line.
Four of the Cardinals’ last five road games against National League opponents have gone OVER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the Giants’ last nine night games.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last three night games at Oracle Park.

San Francisco Giants Player Prop Facts

Rafael Devers has hit a home run in each of the Giants’ last two night games.
Logan Webb has recorded six or more strikeouts in each of his last 11 appearances against opponents that held a losing record.
Jung Hoo Lee has recorded at least one hit in each of his last 10 appearances in night games against teams that held a losing record.
Logan Webb has recorded a win in four of his last five appearances against opponents that held a losing record.

St. Louis Cardinals Player Prop Facts

Willson Contreras has hit a home run in three of his last four road appearances against opponents that held a losing record.
Willson Contreras has recorded a Double in each of his last three road appearances against NL West opponents that held a losing record.
Masyn Winn has recorded at least one hit in each of his last 13 road appearances against NL West opponents that held a losing record.