St. Louis Cardinals vs Philadelphia Phillies Prediction 5/14/25 MLB Picks

The St. Louis Cardinals and the Philadelphia Phillies meet Wednesday in MLB doubleheader action from Citizens Bank Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a St. Louis Cardinals vs. Philadelphia Phillies prediction.

Starting Pitching Matchup

The St. Louis Cardinals will send out Erick Fedde for the start in game one, and Fedde is 3-3 with a 3.86 ERA and 29 strikeouts this season. Game two will see the Cardinals start Sonny Gray, and Gray is 4-1 with a 3.50 ERA and 47 strikeouts this season. The Phillies will start Jesus Luzardo in game one, and Luzardo is 3-0 with a 2.11 ERA and 51 strikeouts this season. Game two will see Aaron Nola take the hill, and Nola is 1-6 with a 4.89 ERA and 50 strikeouts this season.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to build on their 3-2 win over the Phillies in Monday’s series opener to improve to 23-19 on the year. After this series, the Cardinals will head on the road for a series against the Kansas City Royals.

Cardinals Pick Up 9th Straight Win

Brendan Donovan has a team-high 48 hits along with 12 doubles, 3 home runs, and 19 RBIs, while Lars Nootbaar has 26 hits with 4 home runs, 17 RBIs, and 3 stolen bases. Nolan Arenado also has 38 hits with 9 doubles, 6 home runs, and 22 RBIs of his own, and Victor Scott II has 36 hits with 6 doubles, a triple, 8 RBIs, and a team-high 11 stolen bases. Willson Contreras has also chipped in 38 hits with 6 home runs and 23 RBIs of his own this season.

Why the St. Louis Cardinals will win

• The Cardinals have won each of their last nine games.
• The Phillies have lost seven of their last 10 games as home favorites on the first leg of a doubleheader.
• The Cardinals have covered the run line in each of their last nine games.
• The Phillies have failed to cover the run line in 11 of their last 13 games as home favorites on the first leg of a doubleheader.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in two of the Cardinals’ last three games as road underdogs.
• Erick Fedde has recorded a win in three of his last four appearances against NL East opponents.
• Masyn Winn has recorded at least one RBI in five of his last six road appearances after not playing the previous day.
• Masyn Winn has scored at least one run in seven of his last eight road appearances after not playing the previous day.
• Willson Contreras has recorded at least one Single in nine of the Cardinals’ last 10 games as underdogs against NL East opponents.
• Erick Fedde has recorded five or more strikeouts in five of his last six appearances in day games against teams that held a winning record.
• Willson Contreras has recorded at least one hit in each of the Cardinals’ last 11 games as underdogs against NL East opponents.
• Victor Scott II ranks T7th in the league in Steals (11) this season.

Philadelphia Phillies Recap

The Philadelphia Phillies will be out to bounce back from their loss at the hands of the Cardinals in Monday’s series opener to fall to 24-17 on the year. After this series, the Phillies will square off against the Pittsburgh Pirates at home.

Phillies Still Win 7 Of Their Last 10 Despite Monday’s Loss

Nick Castellanos has 42 hits with 10 doubles, including 4 home runs and 21 RBIs, while Kyle Schwarber has 39 hits with a team-high 14 home runs and 32 RBIs as well on the year. Bryce Harper has 6 stolen bases, 7 home runs, and 22 RBIs. Trea Turner also has 48 hits with a team-high 9 stolen bases. Max Kepler has 8 doubles and Bryson Stott has 5 doubles, 2 triples, 3 homers, and 20 RBIs, while Stott also has 8 stolen bases this season.

Why the Philadelphia Phillies will win

• The Phillies have won each of their last 13 home games against National League opponents following a home loss.
• The Cardinals have lost each of their last six day games against the Phillies following a win.
• The Phillies have covered the run line in each of their last four home games against the Cardinals following a loss.
• The Cardinals have failed to cover the run line in 16 of their last 19 road games against the Phillies following a win.

Philadelphia Phillies Player Prop Facts

• Kyle Schwarber has hit a home run in four of the Phillies’ last seven games as home favorites.
• Bryce Harper has recorded at least one Double in four of his last five home appearances against the Cardinals after not playing the previous day.
• J.T. Realmuto has recorded at least one RBI in each of his last seven Wednesday appearances at Citizens Bank Park.
• Kyle Schwarber has scored a run in nine of the Phillies’ last 10 home games against opponents that held a winning record.
• Jesus Luzardo has recorded six or more strikeouts in eight of his last nine appearances with his team as a home favorite against NL opponents.
• Trea Turner has recorded at least one Single in each of the Phillies’ last eight games against NL opponents that held a winning record.
• Nick Castellanos has recorded at least one hit in each of his last 11 appearances with his team as a home favorite against the Cardinals.
• Kyle Schwarber ranks T1st in the league in Home Runs (14) this season.

Total Runs Facts

• Nine of the last 10 games between the Cardinals and Phillies have gone UNDER the total runs line.
• Eight of the Cardinals’ last nine games as underdogs against the Phillies have gone UNDER the total runs line.

St. Louis Cardinals vs. Philadelphia Phillies Prediction

I’m going to ride with the Phillies in game one and the Cardinals in game two. I just think that the Phillies have a significant starting pitching edge in game one with Luzardo starting and Fedde has been far less effective on the road. Game two, I think that Gray gives the Cardinals the edge, and I’m done giving Aaron Nola the benefit of the doubt after the struggles he’s endured to start the season. Give me Philadelphia game one and St. Louis in game two.

Chris Ruffolo's Pick: Philadelphia ML Game One / St. Louis ML Game Two