St. Louis Cardinals vs Milwaukee Brewers Prediction 9/26/2026 Today’s MLB Picks

Nikos Lagouretos

33 minutes ago

Aug 30, 2026; Milwaukee, Wisconsin, USA; Milwaukee Brewers pitcher Dustin May (21) throws a pitch in the first inning against the Texas Rangers at American Family Field. Mandatory Credit: Benny Sieu-Imagn Images

MATCHUP	St. Louis Cardinals	Milwaukee Brewers
Team Records	77-83	101-59
Spread	+1.5 -143	-1.5 119
Moneyline	+157	-192
Total	Over 7.5 (-114)	Under 7.5 (-106)
Where	American Family Field, Milwaukee, Wisconsin
When	Saturday, September 26, 2026
Time	07:10 PM EDT
TV	MLB.TV

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB matchup on Saturday, September 26th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 101-59 record this season and are sitting in the 1st place of the NL Central. They have a 53-26 home record and are coming off an 8-4 home win against the Cardinals.

The Milwaukee Brewers have a .258 batting average this season, .340 OBP and .402 Slugging percentage. Milwaukee’s pitching staff has a 3.52 ERA and 1.18 WHIP. Jackson Chourio is the team’s best hitter with a .286 batting average. Brice Turang leads the team in RBI with 97, while Jake Bauers adds a team-high 26 home runs.

Dustin May (R) is the projected starting pitcher for the Brewers, and he has a 7-9 record, 4.67 ERA and 1.32 WHIP.

St. Louis Cardinals Preview

The St. Louis Cardinals have a 77-83 record this season and are sitting in the 4th place of the NL Central. They have a 39-40 away record and are coming off a 4-8 road loss against the Brewers.

The St. Louis Cardinals have a .241 batting average this season, .314 OBP and .380 Slugging percentage. St. Louis’s pitching staff has a 4.26 ERA and 1.35 WHIP. Alec Burleson is the team’s best hitter with a .280 batting average, adding a team-high 115 RBI. Jordan Walker adds a team-high 29 home runs.

Quinn Mathews (L) is the projected starting pitcher for the Cardinals, and he has a 2-3 record, 3.65 ERA and 1.38 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 26, 2026

Probable Starting Pitcher: Dustin May Record this season: 7-9 ERA: 4.67
Home Record: 5-5
Last 5 against Cardinals: 1-0

Why the Milwaukee Brewers will win

The Brewers have won each of their last nine night games after playing the previous day.
The Cardinals have lost seven of their last eight games at American Family Field.
The Cardinals have failed to cover the run line in seven of their last eight night games against NL opponents.
The Brewers have covered the run line in each of their last five games after playing the previous day.
The Brewers have won the first inning in seven of their last eight home games against opponents that held a losing record.
The Brewers have led after 3 innings in each of their last six night games against NL Central opponents.
The Brewers have led after 5 innings in each of their last six home games against NL Central opponents that held a losing record.

Probable Starting Pitcher: Quinn Mathews Record this season: 2-3 ERA: 3.65
Road Record: 0-3
Last 5 against Brewers: –

Why the St. Louis Cardinals will win

The Cardinals have won four of their last five road games against NL Central opponents following a loss.
The Brewers have lost four of their last five Saturday games as favorites against NL Central opponents.
The Brewers have failed to cover the run line in eight of their last nine games as favorites against the Cardinals following a home win.
The Cardinals have covered the run line in 11 of their last 13 games as underdogs after playing the previous day.
The Cardinals have led after 5 innings in each of their last five Saturday games against the Brewers.

Total Runs Facts

Five of the Brewers’ last six night games against NL Central opponents have gone OVER the total runs line.
Four of the Cardinals’ last five games have gone UNDER the total runs line.
There has been at least one run scored in the first inning in each of the Brewers’ last 11 night games at American Family Field.
There has been at least one run scored in the first inning in each of Quinn Mathews’ last four road appearances as a starter.

Milwaukee Brewers Player Prop Facts

William Contreras has hit a home run in three of his last four home appearances.
Dustin May has recorded four or more strikeouts in each of his last 11 Saturday appearances.
Joey Ortiz has recorded at least one hit in each of his last 11 appearances against NL opponents.

St. Louis Cardinals Player Prop Facts

Jordan Walker has hit a home run in three of the Cardinals’ last four games as underdogs against the Brewers.
JJ Wetherholt has recorded two or more hits in four of his last five road appearances after playing the previous day.
Alec Burleson ranks T9th in the league in Hits (168) this season.

Matchup/League Facts

The Brewers rank 1st in the league for hits this season (1404).
The Brewers rank 1st in the league for batting average this season (.258).
The Cardinals rank 3rd in the league for home runs allowed this season (156).
The Cardinals rank T27th in the league for triples this season (14).

Cardinals vs Brewers Prediction

The Brewers are 9-1 in their last 10 meetings against the Cardinals and have won their last four meetings in Milwaukee.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -190 home favorites. The Brewers keep rolling despite having their playoff position locked and I trust them to keep doing so again today. Dustin May has a 3.87 home ERA while Quinn Mathews a 4.68 road ERA and the Brewers have been annihilating lefties in their last 5 games, with 9.5 runs per game, while the Cardinals average just 2.8 against righties in that span. Take the Brewers to win at home.