St. Louis Cardinals vs Milwaukee Brewers Prediction 9/14/2025 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB game on Sunday, September 14th at the American Family Field the third game of this series, with the Brewers having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 91-58 record this season and are sitting on the first place of the NL Central. They have a 48-26 home record and are 72-72 in over/under. They are coming off a 9-8 home victory over the Cardinals, and have back-to-back wins. Over is 5-1 in their last 6 games and are playing the Cardinals and the Angels next.

The Brewers have a .261 batting average this season, .333 OBP and .408 Slugging percentage. Milwaukee’s pitching staff has a 3.63 ERA and 1.24 WHIP. Brice Turang leads the Brewers with 155 hits, while Christian Yelich leads the team in RBI, with 96, adding a team-high 28 home runs. Sal Frelick is the team’s best hitter with a .296 batting average.

Jose Quintana (L) is the projected starting pitcher for the Brewers, and he has a 11-6 record, 3.88 ERA and 1.28 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-77 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 31-43 road record and are 75-66 in over/under. They are coming off an 8-9 road defeat by the Brewers, and have five straight losses. Over is 3-1 in their last 4 games and are playing the Brewers and the Reds next.

The Cardinals have a .245 batting average this season, .314 OBP and .380 Slugging percentage. Saint Louis’ pitching staff has a 4.30 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 128 hits, and he is the team’s best hitter with a .283 batting average. Wilson Contreras leads the team in RBI, with 79, adding a team-high 20 home runs.

Miles Mikolas (R) is the projected starting pitcher for the Cardinals, and he has a 7-10 record, 4.84 ERA and 1.32 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 14, 2025

• Probable Starting Pitcher: Jose Quintana      Record this season: 11-6      ERA: 3.88
• Home Record: 4-4
• Last 5 against Cardinals: 2-2

Why the Milwaukee Brewers will win

• The Brewers have won each of their last 10 games against NL Central opponents that held a losing record.
• The Cardinals have lost each of their last six road games.
• The Cardinals have failed to cover the run line in each of their last eight Sunday day games.
• The Brewers have covered the run line in nine of their last 10 games against NL Central opponents that held a losing record.
• The Brewers have won the first inning in three of their last four day games.
• The Brewers have led after 3 innings in each of their last five day games against NL Central opponents that held a losing record.
• The Cardinals have trailed after 5 innings in each of their last seven road day games.

• Probable Starting Pitcher: Miles Mikolas      Record this season: 7-10      ERA: 4.84
• Road Record: 3-6
• Last 5 against Brewers: 2-2

Why the St. Louis Cardinals will win

• The Brewers have lost four of their last five games as home favorites after playing the previous day.
• The Cardinals have won six of their last eight games as underdogs against National League opponents following a loss.
• The Brewers have failed to cover the run line in each of their last six home games following a win.
• The Cardinals have covered the run line in nine of their last 10 day games at American Family Field following a loss.
• The Brewers have trailed after 5 innings in four of their last five games.
• The Brewers have trailed after 3 innings in three of their last four games.

Total Runs Facts

• Eight of the Cardinals’ last nine games following an extra innings loss have gone OVER the total runs line.
• Seven of the Brewers’ last eight home games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Cardinals’ last eight road games against NL Central opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in eight of the last 10 day games between the Cardinals and Brewers at American Family Field.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in three of the Brewers’ last five home games against NL Central opponents.
• Jackson Chourio has recorded two hits in each of his last four home appearances against opponents that held a losing record.
• Jose Quintana has recorded a win in each of his last four appearances against NL Central opponents that held a losing record.
• Jose Quintana has recorded six or more strikeouts in three of his last four appearances against NL Central opponents that held a losing record.
• Sal Frelick ranks 9th amongst qualified players for Batting Average (.296) this season.

St. Louis Cardinals Player Prop Facts

• Willson Contreras has hit a home run in five of his last 10 road appearances after playing the previous day.
• Miles Mikolas has recorded a win in eight of his last 10 appearances at American Family Field against opponents that held a winning record.
• Miles Mikolas has recorded three or more strikeouts in each of his last 19 appearances against the Brewers.
• Brendan Donovan has recorded at least one hit in each of his last nine appearances against the Brewers.
• Victor Scott II ranks T10th in the league in Steals (32) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for runs scored this season (760).
• The Brewers rank 2nd in the league for on-base percentage this season (.334).
• The Cardinals rank T29th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1100).

Cardinals vs Brewers Prediction

The Brewers are 6-1 in their last 7 meetings against the Cardinals, and are 5-1 in their last 6 meetings in Milwaukee. Over is 3-1 in their last 4 meetings.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -185 home favorites. Quintana has been a better option than Mikolas this season, but he has been far weaker at home, with a 4.97 home ERA, and he has been in poor form lately, with 14 earned runs in his last three starts. Mikolas has also been terrible on the road, with a 6.54 road ERA, and both teams average 9.6 runs per game combined this season. Both games of this series have been high-scoring ones, with 10 and 17 total runs, so take the over 8.5 runs in this one.