St. Louis Cardinals vs Milwaukee Brewers Prediction 9/13/2025 Today’s MLB Picks

In this article, we will formulate a Cardinals vs Brewers Prediction for this MLB game on Saturday, September 13th at the American Family Field the second game of this series, with the Brewers having the 1-0 lead. Let’s take a look at the prediction for this MLB matchup.

Milwaukee Brewers Preview

The Milwaukee Brewers have a 90-58 record this season and are sitting on the first place of the NL Central. They have a 47-26 home record and are 71-72 in over/under. They are coming off an 8-2 home victory over the Cardinals, which ended their three-game losing streak. Over is 4-1 in their last 5 games and are playing the Cardinals and the Angels next.

The Brewers have a .260 batting average this season, .333 OBP and .408 Slugging percentage. Milwaukee’s pitching staff has a 3.62 ERA and 1.23 WHIP. Brice Turang leads the Brewers with 155 hits, while Christian Yelich leads the team in RBI, with 95, adding a team-high 28 home runs. Sal Frelick is the team’s best hitter with a .294 batting average.

Jacob Misiorowski (R) is the projected starting pitcher for the Brewers, and he has a 5-2 record, 4.09 ERA and 1.09 WHIP.

Saint Louis Cardinals Preview

The Saint Louis Cardinals have a 72-76 record this season and are sitting on the 4th place of the NL Central. The Cardinals have a 31-42 road record and are 74-66 in over/under. They are coming off a 2-8 road defeat by the Mariners, and have three straight losses. Under is 5-3 in their last 8 games and are playing the Brewers and the Reds next.

The Cardinals have a .245 batting average this season, .313 OBP and .378 Slugging percentage. Saint Louis’ pitching staff has a 4.27 ERA and 1.32 WHIP. Alec Burleson leads the Cardinals with 127 hits, and he is the team’s best hitter with a .283 batting average. Wilson Contreras leads the team in RBI, with 78, adding a team-high 20 home runs.

Sonny Gray (R) is the projected starting pitcher for the Cardinals, and he has a 13-8 record, 4.45 ERA and 1.22 WHIP.

St. Louis Cardinals @ Milwaukee Brewers Betting Trends: September 13, 2025

• Probable Starting Pitcher: Jacob Misiorowski      Record this season: 5-2      ERA: 4.09
• Home Record: 3-0
• Last 5 against Cardinals: 1-0

Why the Milwaukee Brewers will win

• The Brewers have won each of their last nine games against NL Central opponents that held a losing record.
• The Cardinals have lost each of their last five road games.
• The Brewers have covered the run line each of their last nine games against NL Central opponents that held a losing record.
• The Cardinals have failed to cover the run line in each of their last six games following a road loss.
• The Brewers have led after 5 innings in each of their last six home games against NL Central opponents that held a losing record.
• The Cardinals have lost the first inning in three of their last four road games against NL Central opponents that held a winning record.
• The Brewers have led after 3 innings in each of their last six home games against NL Central opponents that held a losing record.

• Probable Starting Pitcher: Sonny Gray      Record this season: 13-8      ERA: 4.45
• Road Record: 4-3
• Last 5 against Brewers: 0-3

Why the St. Louis Cardinals will win

• The Brewers have lost each of their last four games as home favorites after playing the previous day.
• The Cardinals have won each of their last six Saturday games as road underdogs.
• The Brewers have failed to cover the run line in eight of their last nine home games after playing the previous day.
• The Cardinals have covered the run line in each of their last six Saturday games as road underdogs.
• The Brewers have trailed after 5 innings in three of their last four games.

Total Runs Facts

• Six of the Brewers’ last seven home games against NL Central opponents have gone OVER the total runs line.
• Six of the Cardinals’ last seven road games against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Brewers’ last seven Saturday night games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in six of the Cardinals’ last seven games as underdogs.

Milwaukee Brewers Player Prop Facts

• Christian Yelich has hit a home run in four of his last five appearances in night games against NL Central teams that held a losing record.
• Christian Yelich has recorded at least one hit in each of his last 19 appearances against NL Central opponents that held a losing record.
• Sal Frelick ranks 9th amongst qualified players for Batting Average (.294) this season.

St. Louis Cardinals Player Prop Facts

• Brendan Donovan has recorded a Double in three of his last four appearances against the Brewers after playing the previous day.
• Willson Contreras has hit a home run in four of his last seven road appearances after playing the previous day.
• Sonny Gray has recorded a win in three of his last four appearances against NL opponents that held a winning record.
• Sonny Gray has recorded six or more strikeouts in 12 of his last 13 appearances with his team as an underdog against NL Central opponents.
• Brendan Donovan has recorded at least one hit in each of his last eight appearances against the Brewers.
• Sonny Gray ranks T8th in the league for Wins (13) this season.

Matchup/League Facts

• The Brewers rank 2nd in the league for runs scored this season (751).
• The Brewers rank 2nd in the league for on-base percentage this season (.333).
• The Cardinals rank T29th in the league for triples this season (8).
• The Cardinals rank 29th in the league for strikeouts this season (1088).

Cardinals vs Brewers Prediction

The Brewers are 5-1 in their last 6 meetings against the Cardinals, and are 4-1 in their last 5 meetings in Milwaukee. Under is 6-3 in their last 9 meetings.

In this Cardinals vs Brewers Prediction, the Brewers are coming as -165 home favorites. Both pitchers have been struggling lately, but Gray has been terrible on the road, with a 5.24 road ERA, and he was torched in his previous start against the Brewers, having given up 6 runs in 4.1 innings pitched. On the flip side, Misiorowski bounced back after a series of bad starts, and he has been excellent at home with a 3-0 record and 2.76 ERA. His previous starts against the Cardinals was a shutout, so I like the Brewers to get the job done once again at home in this one.