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St. Louis Cardinals vs Cincinnati Reds Prediction 8/17/2026 Today’s MLB Picks

Aug 16, 2026; Chicago, Illinois, USA; St. Louis Cardinals pitcher Caleb Ferguson (54) celebrates after defeatinng the Chicago Cubs at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

Aug 16, 2026; Chicago, Illinois, USA; St. Louis Cardinals pitcher Caleb Ferguson (54) celebrates after defeatinng the Chicago Cubs at Wrigley Field. Mandatory Credit: Patrick Gorski-Imagn Images

MATCHUP St. Louis Cardinals Cincinnati Reds
Team Records 63-61 59-64
Where Great American Ball Park, Cincinnati, Ohio
When Monday, August 17, 2026
Time 01:40 PM EDT
TV ESPN Unlmtd
The St. Louis Cardinals and Cincinnati Reds meet Monday in an MLB doubleheader at Great American Ball Park. Here’s a St. Louis Cardinals vs Cincinnati Reds Prediction. This article will include a St. Louis Cardinals vs Cincinnati Reds Pick.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 63-61 on the year and play the Phillies and Orioles next. The St. Louis Cardinals are batting .240 on the season, with a .316 OBP and a .382 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.04 ERA and a 1.34 WHIP. Alec Burleson leads the St. Louis Cardinals with 135 hits and 90 RBI, while Jordan Walker and Ivan Herrera have combined for 247 hits and 140 RBI.

The St. Louis Cardinals will throw out Quinn Mathews and Andre Pallante.

Cincinnati Reds Betting Preview


The Cincinnati Reds are 59-64 on the year and play the Diamondbacks and Giants next. The Cincinnati Reds are batting 226 on the season, have a .306 OBP, and have a .393 slugging percentage. The Cincinnati Reds’ pitching staff has a 4.51 ERA and a 1.40 WHIP. Sal Stewart leads the Cincinnati Reds with 121 hits and 91 RBI, while Elly De La Cruz and Spencer Steer have combined for 188 hits and 96 RBI.

The Cincinnati Reds will throw out TBD and Rhett Lowder.

Why the Cincinnati Reds will win

Why the St. Louis Cardinals will win

Total Runs Facts

Cincinnati Reds Player Prop Facts

St. Louis Cardinals Player Prop Facts

Matchup/League Facts

St. Louis Cardinals vs Cincinnati Reds Prediction


Game 1 Prediction: The jury is still out on Mathews, who has just one career game under his belt, but the Cardinals are coming off a strong week and need to continue if they’re going to sneak into the playoffs. No idea who the Reds are throwing out there, but they’ve been an inconsistent team all season, and they’re hard to trust. The Cards have also had success on the road. Give me the Cardinals in game 1.

Game 2 Prediction: Lowder has been at his best at home this season, but it’s hard to ignore a 5.15 ERA and 1.48 WHIP on the year. Pallante has allowed just 7 hits and 1 run in his last 11.1 innings and has allowed 3 runs in his last 24.2 innings. Pallante is dealing right now. It’s hard to sweep doubleheaders, but I’m rolling with the Cardinals in both games on Monday.

Randy Chambers's Pick: St. Louis Cardinals

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