St. Louis (51-48) vs Arizona (49-50)
July 20, 2025 at 04:10 PM EDT
The Line: Betting Odds: Arizona -1.5 — Over/Under: +9
The St. Louis Cardinals and Arizona Diamondbacks meet Sunday in MLB action at Chase Field. Here’s a St. Louis Cardinals vs Arizona Diamondbacks Prediction. This article will include a St. Louis Cardinals vs Arizona Diamondbacks Pick.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 51-48 on the year and play the Rockies, Padres, and Marlins next. The St. Louis Cardinals are batting .252 on the season, have a .321 OBP, and a .393 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.18 ERA and a 1.28 WHIP. Brendan Donovan leads the St. Louis Cardinals with 103 hits and 36 RBI, while Masyn Winn and Alec Burleson have combined for 175 hits and 76 RBI.
Miles Mikolas gets the ball for the St. Louis Cardinals, and he is 5-6 with a 4.94 ERA and 66 strikeouts this season. Mikolas is 3-2 with a 2.97 ERA and 26 strikeouts in his career against the Arizona Diamondbacks.
Arizona Diamondbacks Betting Preview
The Arizona Diamondbacks are 49-50 on the year and play the Astros, Pirates, and Tigers next. The Arizona Diamondbacks are batting .253 on the season, have a .329 OBP, and a .447 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.60 ERA and a 1.33 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 98 hits and 71 RBI, while Josh Naylor and Lourdes Gurriel Jr. have combined for 187 hits and 105 RBI.
Merrill Kelly gets the ball for the Arizona Diamondbacks, and he is 8-5 with a 3.34 ERA and 113 strikeouts this season. Kelly is 3-1 with a 3.21 ERA and 36 strikeouts in his career against the St. Louis Cardinals.
Why the Arizona Diamondbacks will win
The home team has won nine of the last 10 games between the Cardinals and Diamondbacks.
The Cardinals have lost seven of their last eight road games.
The Cardinals have failed to cover the run line in each of their last four games at Chase Field.
The Diamondbacks have covered the run line each of their last four games against NL Central opponents that held a winning record.
The Cardinals have trailed after 3 innings in five of their last six road games against National League opponents.
The Diamondbacks have led after 5 innings in five of their last six day games at Chase Field against National League opponents.
Why the St. Louis Cardinals will win
The Diamondbacks have lost each of their last five games as favorites against NL Central opponents.
The Cardinals have won five of their last six games as underdogs against NL West opponents following a loss.
The Cardinals have covered the run line in eight of their last nine games as road underdogs against National League opponents following a road loss.
The Diamondbacks have failed to cover the run line in seven of their last eight games as favorites against NL Central opponents.
Arizona Diamondbacks Player Prop Facts
James McCann has recorded at least one hit in each of his last seven appearances with his team as a home favorite against NL opponents.
Merrill Kelly has recorded six or more strikeouts in each of his last five appearances in day games.
James McCann has recorded a Double in three of his last four appearances with his team as a favorite against NL opponents.
Eugenio Suarez has hit at least one home run in each of the Diamondbacks’ last three day games against NL opponents that held a winning record.
St. Louis Cardinals Player Prop Facts
Nolan Arenado has recorded at least one hit in each of his last 13 appearances with his team as an underdog against the Diamondbacks.
Miles Mikolas has recorded four or more strikeouts in each of his last six appearances with the Cardinals as underdogs against NL opponents.
Miles Mikolas has recorded a win in three of his last four road appearances against NL West opponents that held a losing record.
Garrett Hampson has recorded a Double in each of his last three road appearances against the Diamondbacks after playing the previous day.
Nolan Gorman has hit a home run in each of his last two appearances in day games.
St. Louis Cardinals vs Arizona Diamondbacks Prediction
Mikolas has allowed 19 hits and 14 runs in his last 15.2 innings, and he has a 5.58 ERA and .301 allowed batting average in 50 road innings. Kelly has been strong this season with a 3.34 ERA and 1.05 WHIP, and he’s allowed 10 hits and five runs in his last 18 innings. Kelly is allowing just a .206 batting average in 57.2 home innings. The Diamondbacks are on a tear offensively through two second-half games, and they should like this matchup. Give me the Diamondbacks.