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Seattle Mariners vs St. Louis Cardinals Prediction 4/24/2026 Today’s MLB Picks

Apr 22, 2026; Miami, Florida, USA; St. Louis Cardinals designated hitter Ivan Herrera (48) celebrates after hitting a home run against the Miami Marlins during the ninth inning at loanDepot Park. Mandatory Credit: Sam Navarro-Imagn Images

Apr 22, 2026; Miami, Florida, USA; St. Louis Cardinals designated hitter Ivan Herrera (48) celebrates after hitting a home run against the Miami Marlins during the ninth inning at loanDepot Park. Mandatory Credit: Sam Navarro-Imagn Images

MATCHUP Seattle Mariners St. Louis Cardinals
Team Records 11-15 14-10
Where Busch Stadium, St. Louis, Missouri
When Friday, April 24, 2026
Time 08:15 PM EDT
TV MLB.TV
The Seattle Mariners and St. Louis Cardinals meet Friday in MLB action at Busch Stadium. Here’s a Seattle Mariners vs. St. Louis Cardinals Prediction. This article will include a Seattle Mariners vs. St. Louis Cardinals Pick.

Seattle Mariners Betting Preview


The Seattle Mariners are 11-15 on the year and play the Royals and Twins next. The Seattle Mariners are batting .226 on the season, have a .320 OBP, and have a .363 slugging percentage. The Seattle Mariners pitching staff has a 3.42 ERA and a 1.22 WHIP. Randy Arozarena leads the Seattle Mariners with 27 hits and 10 RBI while Cole Young and Julio Rodriguez have combined for 45 hits and 19 RBI.

George Kirby gets the ball for the Seattle Mariners, and he is 3-2 with a 2.97 ERA and 27 strikeouts this season. Kirby is 1-0 with a 4.50 ERA and 7 strikeouts in his career against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview


The St. Louis Cardinals are 14-10 on the year and play the Pirates and Dodgers next. The St. Louis Cardinals are batting .229 on the season and have a .321 OBP, and a .375 slugging percentage. The St. Louis Cardinals pitching staff has a 4.77 ERA and a 1.43 WHIP. Jordan Walker leads the St. Louis Cardinals with 26 hits and 16 RBI while Alec Burleson and JJ Wetherholt have combined for 44 hits and 28 RBI.

Andre Pallante gets the ball for the St. Louis Cardinals, and he is 2-1 with a 4.05 ERA and 12 strikeouts this season. This will be Pallante’s first career game against the Seattle Mariners.

Why the St. Louis Cardinals will win

Why the Seattle Mariners will win

Total Runs Facts

St. Louis Cardinals Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Seattle Mariners vs St. Louis Cardinals Prediction


The Mariners are the better team on paper and Kirby is more trustworthy than Pallante. So, it’s not a surprise to see the M’s favored. However, the Cardinals look like a good team up to this point and they’re at home. While I’m not worried about the Mariners, they have been underwhelming up to this point and are 1-8 on the road. At some point show me something before I lay -140 or higher. I’ll take a shot with the Cardinals at home and the far more favorable price.

Randy Chambers's Pick: St. Louis Cardinals

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