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Seattle Mariners vs San Francisco Giants Prediction 4/6/25 MLB Picks

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San Francisco Giants (7-1) vs Seattle Mariners (3-6)

Game Info: Sunday, April 6, 2025 at 4:05 pm (Oracle Park)

The Line: Betting Odds: San Francisco Giants -125 / Seattle Mariners +105 — Over/Under: 7.5

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In this article, we will formulate a Mariners vs Giants prediction for this MLB game on Sunday, April 6, at Oracle Park in San Francisco, California. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Betting Preview

The Seattle Mariners (3-6, 0-2 Away) split the series with the Athletics and lost tw of three games to the Detroit Tigers at home before losing the opening two games of a three-game series against the San Francisco Giants. The Mariners fell short in extra innings in Game 1, while they suffered a 4-1 defeat last night. Bryce Miller took a loss after allowing four runs on seven hits with four strikeouts and three walks in 5.1 innings.

This year, the Mariners average 3.11 runs per game (26th in the MLB) on a .202/.312/.333 triple-slash. When it comes to pitching, the Mariners’ staff has a 4.52 ERA (19th) and 1.43 WHIP (25th). Jorge Polanco leads the Mariners with a .450 batting average, two home runs, and eight RBI this season.

Bryan Woo will take the mound for the Mariners on Sunday. The 25-year-old righty had a 9-3 record in 22 starts last year with a 2.89 ERA and 0.90 WHIP in 121.1 innings. This season, Woo is 1-0 with a 1.50 ERA in 6.0 innings.

San Francisco Giants Betting Preview

The San Francisco Giants (7-1, 2-0 Home) came home from a road trip to Cincinnati and Houston and beat the Seattle Mariners in the opening two games of a three-game series. The Giants won two of three games against the Reds and, surprisingly, swept the Astros before defeating the Mariners 10-9 and 4-1. In the latest win, Matt Chapman led the team with two RBI, while Robbie Ray got a win after allowing one run on four hits with two strikeouts and five walks over 6.0 innings of work.

This season, the Giants average 5.50 runs per game (5th in the MLB) on a .241/.313/.432 slash line. Regarding pitching, the Giants’ staff has a 2.71 ERA (4th) and 1.20 WHIP (13th). Wilmer Flores leads the Giants with a .250 batting average, four home runs, and 11 RBI this season.

The projected starting pitcher for the Giants is Jordan Hicks, who had a 4-7 record in 20 starts last year with a 4.10 ERA and 1.45 WHIP in 109.2 innings. Hicks is 1-0 this season, with a 0.00 ERA in 6.0 innings.

Why the Mariners will beat the Giants

Why the Giants will beat the Mariners

Total Runs Facts

Mariners vs Giants Prediction

The teams have traded victories over the past few years, as each recorded five wins in the last ten games. The Giants were better in the previous three H2Hs. Bryan Woo dominated the Giants last year as he allowed a 1.29 ERA in 7.0 innings and had a .148 BA in 27 at-bats. Jordan Hicks struggled in his previous game against Seattle; he didn’t complete a single innings as he came in as a reliever and posted a 13.50 ERA. Bth Woo and Hicks were impressive in their first respective starts of this season, and I am backing them to have another strong outing. Both will record quality starts, so I am going with Under.

Oliver Zivic's Pick: Under 7.5

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