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Seattle Mariners vs Houston Astros Prediction 5/24/25 MLB Picks

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Houston Astros (26-25) vs Seattle Mariners (29-21)

Game Info: Saturday, May 24, 2025 at 4:10 pm (Daikin Park)

The Line: Betting Odds: Houston Astros -122 / Seattle Mariners +102 — Over/Under: 7.5

(Get latest betting odds)

The Seattle Mariners are visiting Houston Astros on Saturday, May 24th at the Daikin Park in the third game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs Houston Astros Prediction. We will examine:

The Houston Astros recent form and player performance

The Seattle Mariners recent form and player performance

Recent betting trends and streaks involving the Houston Astros

Recent betting trends and streaks involving the Seattle Mariners

Recent betting trends in games played between the Seattle Mariners vs Houston Astros

A summary that ties it all together and produces a favorable betting outcome for A Seattle Mariners vs Houston Astros game

Houston Astros Preview

The Houston Astros have a 26-25 record this season and are sitting on the second place of the AL West. The Astros have a 16-10 home record and 21-28 in over/under. They are coming off a 3-5 home defeat by the Mariners, and are 1-3 in their last 4 games. Under is 8-3 in their last 11 games, and they are playing the Athletics and the Rays next.

The Astros have a .250 batting average this season, .320 OBP and .383 slugging percentage. Houston’s pitching staff has a 3.48 ERA and 1.16 WHIP. Jeremy Pena leads the Astros with 56 hits, while Isaac Paredes leads the team in RBI with 31, adding a team-high 11 home runs. Jake Meyers is the team’s best hitter, with a .309 batting average.

Framber Valdez (L) will take the mound for the Astros, and he has a 3-4 record, 3.57 ERA and 1.13 WHIP. He has been better at home with a 2.77 ERA across four home starts, and in his previous start against the Mariners this season, he had a shutout performance in 6 innings pitched. Framber Valdez is 6-3 with an ERA of 3.33 and 96 strikeouts in 17 appearances against the Mariners in his career.

Seattle Mariners Preview

The Seattle Mariners have a 29-21 record this season and are sitting on the first place of the AL West. The Mariners have a 16-10 road record and 27-21 in over/under They are coming off a 5-3 road victory over the Astros, and are 6-2 in their last 8 games. Under is 8-2 in their last 10 games and they are playing the Nationals and the Twins next.

The Mariners have a .237 batting average this season, .326 OBP and .402 Slugging percentage. Seattle’s pitching staff has a 3.72 ERA and 1.31 WHIP. Cal Raleigh leads the Mariners in hits with 47, in RBI with 35, and in home runs with 17. JP Crawford is the team’s best hitter with a .266 batting average.

Bryan Woo (R) will take the mound for the Mariners, and he has a 5-1 record, 2.65 ERA and 0.87 WHIP. He has been weaker on the road with a 3.52 ERA across six road starts, and he has been in excellent form with just one earned run in 13.1 innings pitched in his last two starts. Bryan Woo has a 1-0 record with an ERA of 2.31 and 9 strikeouts in 2 appearances against the Astros in his career.

Why the Houston Astros will win

Why the Seattle Mariners will win

Total Runs Facts

Matchup/League Facts

Seattle Mariners vs Houston Astros Prediction

The Mariners are 6-3 in their last 9 meetings against the Astros, and are 5-2 in their last 7 visits in Houston. In this Seattle Mariners vs Houston Astros Prediction, the Astros are coming as -120 home favorites. This should be closer to a pickem, as the Mariners have the better overall record, and the same number of road wins, as the Astros have at home. Both teams have top-10 bullpens with a combined 6.27 ERA, and both pitchers have also been sharp this season. Both teams are also 16-5 to the under in their last 21 games combined, so everything aligns for another low-scoring affair today. Take the under 7.5 runs.

Nikos Lagouretos's Pick: Under 7.5

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