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Seattle Mariners vs Houston Astros Prediction 5/12/2026 Today’s MLB Picks

May 6, 2026; Seattle, Washington, USA;  Seattle Mariners starting pitcher Bryan Woo (22) delivers in the second inning against the Atlanta Braves at T-Mobile Park. Mandatory Credit: Kevin Ng-Imagn Images

May 6, 2026; Seattle, Washington, USA; Seattle Mariners starting pitcher Bryan Woo (22) delivers in the second inning against the Atlanta Braves at T-Mobile Park. Mandatory Credit: Kevin Ng-Imagn Images

MATCHUP Seattle Mariners Houston Astros
Team Records 20-22 16-26
Spread -1.5 109 +1.5 -131
Moneyline -149 +123
Total Over 8.5 (-120) Under 8.5 (100)
Where Daikin Park, Houston, Texas
When Tuesday, May 12, 2026
Time 08:10 PM EDT
TV MLB.TV
In this article, we will formulate a Mariners vs Astros Prediction for this MLB matchup on Tuesday, May 12th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Houston Astros Preview


The Houston Astros have a 16-26 record this season and are sitting in the fifth place of the AL West. They have a 9-11 home record and are coming off a 1-3 loss at home against the Mariners. They will face the Rangers and the Twins next.

The Astros have a .258 batting average this season, .333 OBP and .425 Slugging percentage. Houston’s pitching staff has a 5.50 ERA and 1.58 WHIP. Yordan Alvarez is the team’s best hitter with a .314 batting average, also adding a team‑high 13 home runs. Christian Walker leads the team in RBI with 27.

Tatsuya Imai (R) is the projected starting pitcher for the Astros, and he has a 1-0 record, 7.27 ERA and 2.08 WHIP.

Seattle Mariners Preview


The Seattle Mariners have a 20-22 record this season and are sitting in the second place of the AL West. They have a 8-11 away record and are coming off a 3-1 win on the road against the Astros. They will face the Padres and the White Sox next.

The Mariners have a .229 batting average this season, .317 OBP and .376 Slugging percentage. Seattle’s pitching staff has a 3.71 ERA and 1.23 WHIP. Randy Arozarena is the team’s best hitter with a .285 batting average. Luke Raley leads the team in RBI with 23, also adding a team‑high 8 home runs.

Bryan Woo (R) is the projected starting pitcher for the Mariners, and he has a 2-2 record, 4.02 ERA and 1.00 WHIP.

Seattle Mariners @ Houston Astros Betting Trends: May 12, 2026


Why the Houston Astros will win


Why the Seattle Mariners will win

Total Runs Facts

Houston Astros Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Mariners vs Astros Prediction


The Mariners have won their last 8 meetings against the Astros and have won their last three visits in Houston. Over is 7-3 in their last 10 meetings.

In this Mariners vs Astros Prediction, the Mariners are coming as -155 road favorites. The Mariners have been dominating the Astros this season, having won all of their five meetings, with their last three meetings having a combined 15-4 score. The Astros have lost three straight, having scored just two runs in that span and will have to face Bryan Woo today, so things are not looking good. The bullpen difference is also huge, as the Mariners rank third in bullpen ERA, while the Astros are dead last, so keep it simple and take the Mariners on the moneyline in this one.

Nikos Lagouretos's Pick: Seattle Mariners ML

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