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Seattle Mariners vs Cleveland Guardians Prediction 6/26/2026 Today’s MLB Picks

May 16, 2026; Cleveland, Ohio, USA; Cleveland Guardians starting pitcher Joey Cantillo (54) delivers a pitch in the second inning against the Cincinnati Reds at Progressive Field. Mandatory Credit: David Richard-Imagn Images

May 16, 2026; Cleveland, Ohio, USA; Cleveland Guardians starting pitcher Joey Cantillo (54) delivers a pitch in the second inning against the Cincinnati Reds at Progressive Field. Mandatory Credit: David Richard-Imagn Images

MATCHUP Seattle Mariners Cleveland Guardians
Team Records 41-41 42-39
Spread -1.5 153 +1.5 -187
Moneyline -108 -112
Total Over 7.5 (-119) Under 7.5 (-102)
Where Progressive Field, Cleveland, Ohio
When Friday, June 26, 2026
Time 07:10 PM EDT
TV MLB.TV
In this article, we will formulate a Mariners vs Guardians Prediction for this MLB matchup on Friday, June 26th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Cleveland Guardians Preview


The Cleveland Guardians have a 42-39 record this season and are sitting in the 2nd place of the AL Central. They have a 19-17 home record and are coming off a 4-3 road win against the White Sox. They will face the Rangers and the White Sox next.

The Guardians have a .228 batting average this season, .313 OBP and .366 Slugging percentage. Cleveland’s pitching staff has a 3.79 ERA and 1.25 WHIP. Brayan Rocchio is the team’s best hitter with a .269 batting average. Chase DeLauter leads the team in RBI with 34, while Angel Martinez adds a team-high 11 home runs.

Joey Cantillo (L) is the projected starting pitcher for the Guardians, and he has a 6-3 record, 4.05 ERA and 1.40 WHIP.

Seattle Mariners Preview


The Seattle Mariners have a 41-41 record this season and are sitting in the 1st place of the AL West. They have a 19-22 road record and are coming off a 1-5 road defeat against the Pirates. They will face the Angels and the Blue Jays next.

The Mariners have a .231 batting average this season, .311 OBP and .384 Slugging percentage. Seattle’s pitching staff has a 3.71 ERA and 1.19 WHIP. Randy Arozarena is the team’s best hitter with a .284 batting average. Julio Rodriguez leads the team in RBI with 38, while Luke Raley adds a team-high 14 home runs.

Luis Castillo (R) is the projected starting pitcher for the Mariners, and he has a 2-6 record, 5.22 ERA and 1.40 WHIP.

Seattle Mariners @ Cleveland Guardians Betting Trends: June 26, 2026


Why the Cleveland Guardians will win


Why the Seattle Mariners will win

Total Runs Facts

Cleveland Guardians Player Prop Facts

Seattle Mariners Player Prop Facts

Matchup/League Facts

Mariners vs Guardians Prediction


Both teams are tied 4-4 in their last 8 meetings and the Guardians have won two of their last three meetings in Cleveland.

In this Mariners vs Guardians Prediction, the Guardians are coming as -115 home favorites. I like the Guardians in this one at home, as the Mariners have scored just two runs in their last two games and Castillo has been shaky this season. On top of that, Seattle has been struggling against lefties and Cantillo is coming off back-to-back quality starts and has been better at home. Take the Guardians in this one.

Nikos Lagouretos's Pick: Cleveland Guardians ML

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