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Seattle Mariners vs Chicago White Sox Prediction 5/20/25 MLB Picks

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Chicago White Sox (14-34) vs Seattle Mariners (27-19)

Game Info: Tuesday, May 20, 2025 at 7:40 pm (Rate Field)

The Line: Betting Odds: Chicago White Sox +150 / Seattle Mariners -180 — Over/Under: 8.5

(Get latest betting odds)

The Seattle Mariners and the Chicago White Sox meet Tuesday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Seattle Mariners did not have a starting pitcher announced at the time that this article was posted. The Chicago White Sox will send out Bryse Wilson for the start here, and Wilson is 0-2 with a 6.00 ERA and 19 strikeouts this season. This will be Wilson’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 5-1 series-opening win over the White Sox from Monday’s matchup to improve to 27-19 on the year. After this series, the Mariners will head on the road for a division series against the Houston Astros.

Mariners Win Four In A Row

Jorge Polanco has 36 hits, including 10 home runs and 29 RBIs, while Cal Raleigh has 40 hits with 8 doubles, a team-high 15 home runs, and 32 RBIs. Randy Arozarena has 37 hits with 10 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 43 hits with a pair of triples, 7 home runs, 21 RBIs, and 5 stolen bases. Dylan Moore has 7 homers and 7 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 22 RBIs, while J.P. Crawford has 41 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

Seattle Mariners Player Prop Facts

Chicago White Sox Recap

The Chicago White Sox come into this game looking to bounce back from their loss at the hands of the Mariners in Monday’s matchup, falling to 14-34 on the year. After this series, the White Sox will take on the Texas Rangers at home.

White Sox Lose 5th Straight

Lenyn Sosa leads the White Sox with 41 hits, including 7 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 10 doubles and 21 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 18 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

Chicago White Sox Player Prop Facts

Total Runs Facts

Seattle Mariners vs. Chicago White Sox Prediction

I’m on the Mariners -1.5 here. It would be nice to know who the Mariners are throwing out for the start here, but I think that we’re at a point with the White Sox where it doesn’t matter who the other team is starting here; Chicago is on auto-fade until further notice. The offense continues to be lacklustre for the White Sox, and while Seattle’s cooled off in some of their recent outings, I still think the Mariners are miles ahead of the better team in this matchup, so I’ll roll with the Mariners -1.5 for another sizeable win in this one.

Chris Ruffolo's Pick: Seattle Mariners -1.5

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