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Seattle Mariners vs Chicago White Sox Prediction 5/19/25 MLB Picks

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Chicago White Sox (14-33) vs Seattle Mariners (26-19)

Game Info: Monday, May 19, 2025 at 7:40 pm (Rate Field)

The Line: Betting Odds: Chicago White Sox +170 / Seattle Mariners -205 — Over/Under: 8

(Get latest betting odds)

The Seattle Mariners and the Chicago White Sox meet Monday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Seattle Mariners vs. Chicago White Sox prediction.

Starting Pitching Matchup

The Seattle Mariners will start Luis Castillo here, and Castillo is 3-3 with a 3.65 ERA and 39 strikeouts this season. In his career, Castillo is 1-0 with a 2.33 ERA and 23 strikeouts against the White Sox. The Chicago White Sox will start Davis Martin here, and Martin is 2-4 with a 3.65 ERA and 33 strikeouts this season. This will be Martin’s first career start against the Mariners.

Seattle Mariners Recap

The Seattle Mariners come into this game looking to build on their 6-1 win over the San Diego Padres in Sunday’s series finale to improve to 26-19 on the year. After this series, the Mariners will head on the road for a division series against the Houston Astros.

Mariners Win Three Straight

Jorge Polanco has 36 hits, including 10 home runs and 29 RBIs, while Cal Raleigh has 40 hits with 8 doubles, a team-high 15 home runs, and 32 RBIs. Randy Arozarena has 37 hits with 10 doubles, 6 home runs, 21 RBIs, and 9 stolen bases. Julio Rodriguez also has 43 hits with a pair of triples, 7 home runs, 21 RBIs, and 5 stolen bases. Dylan Moore has 7 homers and 7 stolen bases as well this season. Rowdy Tellez has also added 8 home runs and 22 RBIs, while J.P. Crawford has 41 hits with 5 doubles, 4 home runs, and 19 RBIs.

Why the Seattle Mariners will win

Seattle Mariners Player Prop Facts

Chicago White Sox Recap

The Chicago White Sox come into this game looking to rebound from a 6-2 loss at the hands of the Chicago Cubs last time out to slip to 14-33 on the year. After this series, the White Sox will take on the Texas Rangers at home.

White Sox Drop Four In A Row

Lenyn Sosa leads the White Sox with 41 hits, including 7 doubles and 11 RBIs. Andrew Benintendi has 19 hits, including 5 home runs, 12 RBIs, and a .224 batting average, while Miguel Vargas has a team-high 10 doubles and 21 RBIs. Brooks Baldwin has also added 16 RBIs, while Luis Robert Jr. has a team-high 17 stolen bases along with 17 RBIs so far this season. Andrew Vaughn has 5 home runs and 18 RBIs as well as 8 doubles this season.

Why the Chicago White Sox will win

Chicago White Sox Player Prop Facts

Total Runs Facts

Seattle Mariners vs. Chicago White Sox Prediction

I’m on the Mariners -1.5 here. I get the case to be made for a home underdog in some spots, but the White Sox just are not a team I want to take a stab at right now in any way, shape, or form. The Mariners have some huge confidence after their sweep of the Padres, and while Castillo’s struggled on the road this season, this is just a huge mismatch in favor of the Mariners, so give me Seattle -1.5 in this one.

Chris Ruffolo's Pick: Seattle Mariners -1.5

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