| MATCHUP | San Francisco Giants | San Diego Padres |
|---|---|---|
| Team Records | 61-66 | 71-56 |
| Where | Petco Park, San Diego, California | |
| When | Wednesday, August 20, 2025 | |
| Time | 09:40 PM EDT | |
| TV | MLB Net | |
The San Francisco Giants and the San Diego Padres meet Wednesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Francisco Giants vs. San Diego Padres prediction.
Starting Pitching Matchup
The San Francisco Giants will send out Landen Roupp for the start here and Roupp is 7-6 with a 3.45 ERA and 100 strikeouts this season. In his career, Roupp is 0-1 with a 2.30 ERA and 13 strikeouts against the Padres. JP Sears will get the start for the Padres here and is 7-10 with a 5.12 ERA and 101 strikeouts this season. In his career, Sears is 2-1 with a 1.82 ERA and 26 strikeouts against San Francisco.
San Francisco Giants Recap
The San Francisco Giants come into this game looking to rebound from a 5-1 loss at the hands of the Padres last time out to sit at 61-65 on the year. After this series, the Giants will head on the road for a series against the Milwaukee Brewers.
Giants Drop 8 Of Their Last 10 Games
Jung Hoo Lee has 116 hits including a team-high 28 doubles along with 10 triples, 6 home runs and 46 RBIs with 10 stolen bases while Heliot Ramos has 128 hits with 21 doubles, 15 home runs and 53 RBIs. Wilmer Flores also 13 home runs and 63 RBIs while Tyler Fitzgerald has a team-high 9 stolen bases as well on the year. Matt Chapman also has 79 hits with 16 home runs and 44 RBIs along with 15 doubles and Willy Adames has 103 hits with 18 doubles, 19 home runs and 62 RBIs of his own this season.
Why the San Francisco Giants will win
- The Giants have won four of their last five games as road underdogs against National League opponents following a loss.
- The Padres have lost each of their last three games as favorites against NL West opponents following a home win.
- The Padres have failed to cover the run line in each of their last seven Wednesday night games as favorites against National League opponents.
- The Giants have covered the run line in each of their last four road games against National League opponents following a loss.
San Francisco Giants Player Prop Facts
- Rafael Devers has hit a home run in two of the Giants’ last three games as road underdogs.
- Jung Hoo Lee has recorded a Double in five of the Giants’ last six road games against opponents that held a winning record.
- Dominic Smith has recorded at least one hit in each of his last 12 appearances in night games.
- Rafael Devers ranks 10th amongst qualified players for On Base Percentage (.376) this season.
San Diego Padres Recap
The San Diego Padres come into this game looking to add on to their victory over the Giants from Tuesday’s matchup to improve to 70-56 this season. After this set, the Padres will head home to take on the Los Angeles Dodgers in a division series rematch.
Padres Snap Four-Game Losing Streak
Manny Machado has 140 hits including a team-high 30 doubles, 20 home runs, 72 RBIs and 11 stolen bases while Fernando Tatis Jr. has 123 hits with 17 home runs and 50 RBIs along with 24 stolen bases of his own this season. Luis Arraez has added 141 hits with 26 doubles, 4 triples, 6 home runs and 46 RBIs while Jackson Merrill’s added 91 hits with 9 home runs and 51 RBIs as well. Xander Bogaerts also has 28 doubles and 19 stolen bases as well this season. Gavin Sheets also has 17 doubles, 15 home runs and 54 RBIs as well this season.
Why the San Diego Padres will win
- The Padres have won eight of their last nine games against the Giants following a win.
- The Giants have lost eight of their last nine games against the Padres following a loss.
- The Padres have covered the run line in seven of their last eight home games following a home win.
- The Giants have failed to cover the run line in seven of their last eight games against NL West opponents following a loss.
San Diego Padres Player Prop Facts
- Xander Bogaerts has hit a home run in three of the Padres’ last eight games as favorites.
- Xander Bogaerts has recorded a Double in four of the Padres’ last five games against opponents that held a losing record.
- JP Sears has recorded five or more strikeouts in each of his last four home appearances.
- Manny Machado has recorded at least one hit in each of the Padres’ last eight games against the Giants.
- JP Sears has recorded a win in five of his last six appearances with his team as a home favorite .
- Luis Arraez ranks T3rd in the league in Hits (142) this season.
Total Runs Facts
- Each of the Padres’ last seven night games against NL West opponents have gone UNDER the total runs line.
- Each of the Giants’ last five night games after playing the previous day have gone UNDER the total runs line.
San Francisco Giants vs. San Diego Padres Prediction
I’m on the Padres in this one. I think that Sears gets a really favorable matchup here, as the Giants have been horrible against left-handed pitching for the better part of the second half of the season so far and I don’t expect it to get better here. Roupp has a lot of upside, but he’s had issues of his own, and the Padres have been really solid against right-handed pitching and I think they get it done here. Give me San Diego.