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San Francisco Giants vs San Diego Padres Prediction 8/18/2025 Today’s MLB Picks

Aug 17, 2025; San Francisco, California, USA; San Francisco Giants shortstop Willy Adames (2) (obscured) dumps a cooler of sports drink over right fielder Drew Gilbert (61) to celebrate the Giants defeat of the Tampa Bay Rays in the ninth inning at Oracle Park. Mandatory Credit: Robert Edwards-Imagn Images

Aug 17, 2025; San Francisco, California, USA; San Francisco Giants shortstop Willy Adames (2) (obscured) dumps a cooler of sports drink over right fielder Drew Gilbert (61) to celebrate the Giants defeat of the Tampa Bay Rays in the ninth inning at Oracle Park. Mandatory Credit: Robert Edwards-Imagn Images

MATCHUP San Francisco Giants San Diego Padres
Team Records 61-64 69-56
Where Petco Park, San Diego, California
When Monday, August 18, 2025
Time 09:40 PM EDT
TV Padres.TV

The San Francisco Giants and San Diego Padres meet Monday in MLB action at Petco Park. Here’s a San Francisco Giants vs San Diego Padres Prediction. This article will include a San Francisco Giants vs San Diego Padres Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 60-64 on the year and play the Brewers, Cubs, and Orioles next. The San Francisco Giants are batting .233 on the season, have a .309 OBP, and a .374 slugging percentage. The San Francisco Giants pitching staff has a 3.70 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 126 hits and 52 RBI, while Jung Hoo Lee and Willy Adames have combined for 217 hits and 108 RBI. 

Robbie Ray gets the ball for the San Francisco Giants, and he is 9-6 with a 2.98 ERA and 152 strikeouts this season. Ray is 6-7 with a 4.25 ERA and 147 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview

The San Diego Padres are 69-55 on the year and play the Dodgers, Mariners, and Twins next. The San Diego Padres are batting .252 on the season, have a .322 OBP, and a .383 slugging percentage. The San Diego Padres pitching staff has a 3.67 ERA and a 1.20 WHIP. Luis Arraez leads the San Diego Padres with 140 hits and 46 RBI while Manny Machado and Fernando Tatis Jr. have combined for 262 hits and 122 RBI.

Nestor Cortes gets the ball for the San Diego Padres, and he is 1-1 with a 5.71 ERA and 17 strikeouts this season. Cortes is 0-0 with a 4.00 ERA and 13 strikeouts in his career against the San Francisco Giants.

Why the San Diego Padres will win

Why the San Francisco Giants will win

San Diego Padres Player Prop Facts

San Francisco Giants Player Prop Facts

San Francisco Giants vs San Diego Padres Prediction

Cortes has been sharp in two starts since coming over from Milwaukee, but he still has limited reps under his belt this season and has an ERA well over five and a 1.56 WHIP. It’s hard to take Cortes seriously right now. Ray is an all-star with a 2.98 ERA and 1.14 WHIP, and he’s allowing a .190 batting average in 68.2 road innings. The Giants are also coming off a feel good win over the Rays, which could be a turning point in what has been a disaster second half. With the better pitcher, I’ll lean Giants in this spot.

Randy Chambers's Pick: San Francisco Giants

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