San Francisco (60-64) vs San Diego (69-55)
August 18, 2025 at 09:40 PM EDT
The Line: Betting Odds: San Diego -1.5 — Over/Under: +7.5
The San Francisco Giants and San Diego Padres meet Monday in MLB action at Petco Park. Here’s a San Francisco Giants vs San Diego Padres Prediction. This article will include a San Francisco Giants vs San Diego Padres Pick.
San Francisco Giants Betting Preview
The San Francisco Giants are 60-64 on the year and play the Brewers, Cubs, and Orioles next. The San Francisco Giants are batting .233 on the season, have a .309 OBP, and a .374 slugging percentage. The San Francisco Giants pitching staff has a 3.70 ERA and a 1.28 WHIP. Heliot Ramos leads the San Francisco Giants with 126 hits and 52 RBI, while Jung Hoo Lee and Willy Adames have combined for 217 hits and 108 RBI.
Robbie Ray gets the ball for the San Francisco Giants, and he is 9-6 with a 2.98 ERA and 152 strikeouts this season. Ray is 6-7 with a 4.25 ERA and 147 strikeouts in his career against the San Diego Padres.
San Diego Padres Betting Preview
The San Diego Padres are 69-55 on the year and play the Dodgers, Mariners, and Twins next. The San Diego Padres are batting .252 on the season, have a .322 OBP, and a .383 slugging percentage. The San Diego Padres pitching staff has a 3.67 ERA and a 1.20 WHIP. Luis Arraez leads the San Diego Padres with 140 hits and 46 RBI while Manny Machado and Fernando Tatis Jr. have combined for 262 hits and 122 RBI.
Nestor Cortes gets the ball for the San Diego Padres, and he is 1-1 with a 5.71 ERA and 17 strikeouts this season. Cortes is 0-0 with a 4.00 ERA and 13 strikeouts in his career against the San Francisco Giants.
Why the San Diego Padres will win
- The Padres have won each of their last 11 home games against National League opponents following a loss.
- The Giants have lost seven of their last eight games.
- The Giants have failed to cover the run line in each of their last six road games against NL West opponents following a home win.
- The Padres have covered the run line in eight of their last nine games against the Giants.
- The Padres have led after 5 innings in each of their last three games as favorites.
Why the San Francisco Giants will win
- The Padres have lost each of their last seven games against the Giants at Petco Park following a road loss.
- The Giants have won nine of their last 10 Monday games as underdogs against the Padres.
- The Padres have failed to cover the run line in seven of their last eight games at Petco Park against National League opponents that held a losing record.
- The road team has covered the run line in six of the last seven games between the Giants and Padres.
- The Giants have led after 5 innings in four of their last five games as road underdogs against National League opponents.
- The Giants have led after 3 innings in each of their last three road games against NL West opponents.
San Diego Padres Player Prop Facts
- Xander Bogaerts has hit a home run in two of the Padres’ last three games against the Giants at Petco Park.
- Manny Machado has recorded at least one hit in each of the Padres’ last 11 Monday games as favorites.
- Xander Bogaerts has recorded a Double in each of the Padres’ last three games against NL West opponents that held a losing record.
- Manny Machado ranks T4th in the league in Hits (139) this season.
San Francisco Giants Player Prop Facts
- Casey Schmitt has hit a home run in two of his last three road appearances against NL West opponents.
- Rafael Devers has recorded at least one hit in each of the Giants’ last 11 games as road underdogs.
- Jung Hoo Lee has recorded a Double in each of the Giants’ last four road games against NL opponents that held a winning record.
San Francisco Giants vs San Diego Padres Prediction
Cortes has been sharp in two starts since coming over from Milwaukee, but he still has limited reps under his belt this season and has an ERA well over five and a 1.56 WHIP. It’s hard to take Cortes seriously right now. Ray is an all-star with a 2.98 ERA and 1.14 WHIP, and he’s allowing a .190 batting average in 68.2 road innings. The Giants are also coming off a feel good win over the Rays, which could be a turning point in what has been a disaster second half. With the better pitcher, I’ll lean Giants in this spot.