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San Francisco Giants vs San Diego Padres Prediction 3/31/2026 Today’s MLB Picks

Sep 23, 2025; San Francisco, California, USA; San Francisco Giants starting pitcher Logan Webb (62) throws against the St. Louis Cardinals during the fourth inning at Oracle Park. Mandatory Credit: Eakin Howard-Imagn Images

Sep 23, 2025; San Francisco, California, USA; San Francisco Giants starting pitcher Logan Webb (62) throws against the St. Louis Cardinals during the fourth inning at Oracle Park. Mandatory Credit: Eakin Howard-Imagn Images

MATCHUP San Francisco Giants San Diego Padres
Team Records 1-3 1-3
Spread -1.5 123 +1.5 -149
Moneyline -143 +119
Total Over 7.5 (-118) Under 7.5 (-102)
Where Petco Park, San Diego, California
When Tuesday, March 31, 2026
Time 09:40 PM EDT
TV MLB.TV

In this article, we will formulate a Giants vs Padres Prediction for this MLB matchup on Tuesday, March 31st. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Preview

The San Diego Padres have a 1-3 record this season and are sitting in the second place of the NL West. They have a 1-3 home record and are coming off a 2-3 home defeat by the Giants. Their previous three games were a 3-0 home win, a 5-2 home loss, and an 8-2 home loss to the Tigers

The Padres have a .181 batting average this season, .252 OBP and .260 Slugging percentage. San Diego’s pitching staff has a 3.75 ERA and 1.25 WHIP. Ramon Laureano is the team’s best hitter with a .357 batting average, also leading the team in RBI with 3 and adding a team-high one home run.

Logan Webb (R) is the projected starting pitcher for the Padres, and he has a 0-1 record, 10.80 ERA and 2.00 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 0-3 record this season and are sitting in the last place of the NL West. They have a 1-0 road record and are coming off a 3-2 road victory over the Padres. They lost their previous three home games to the Yankees by scores of 3-1, 3-0, and 7-0. 

The Giants have a .154 batting average this season, .230 OBP and .211 Slugging percentage. San Francisco’s pitching staff has a 3.50 ERA and 1.08 WHIP. Heliot Ramos is the team’s best hitter with a .214 batting average, while Matt Chapman leads the team with one RBI and Harrison Badge adds a team-high one home run.

German Marquez (R) is the projected starting pitcher for the Giants, and last season he had a 3-16 record, 6.70 ERA and 1.71 WHIP.

San Francisco Giants @ San Diego Padres Betting Trends: March 31, 2026

Why the San Diego Padres will win

Why the San Francisco Giants will win

Total Runs Facts

San Diego Padres Player Prop Facts

San Francisco Giants Player Prop Facts

Matchup/League Facts

Giants vs Padres Prediction

The Padres are 6-2 in their last 8 meetings against the Giants and are 3-1 in their last 4 meetings in San Diego.   

In this Giants vs Padres Prediction, the Giants are coming as -140 home favorites. The Giants bounced back yesterday and got their first win of the season and now both teams have identical 1-3 records. The Giants are putting Logan Webb on the mound who was torched in his first start of the season by the Yankees but he will have a much easier matchup against the Padres squad that has a measly .181 batting average so far. Padres are putting German Marquez on the mound, who had been terrible last season and was torched in his three starts against the Giants, with 15 earned runs in 13.2 innings pitched. I expect a bounce-back performance by Webb that will lead the Giants to another victory in this matchup.

Nikos Lagouretos's Pick: San Francisco Giants ML

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