San Francisco Giants vs Pittsburgh Pirates Prediction 07/29/2025 Picks

In this article, we will formulate a Pittsburgh Pirates vs San Francisco Giants Prediction for this MLB game on Tuesday, July 29^th at the Oracle Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

San Francisco Giants Preview

The San Francisco Giants have a 54-53 record this season and are sitting on the third place of the NL West. They have a 28-24 home record and are 50-53 in over/under. They are coming off a 5-6 home defeat by the Pirates, and are 2-9 in their last 11 games. Over is 6-1-2 in their last 9 games and are playing the Mets and the Pirates again next.

The Giants have a .233 batting average this season, .312 OBP and .376 Slugging percentage. San Francisco’s pitching staff has a 3.66 ERA and 1.28 WHIP.  Heliot Ramos leads the Giants with 109 hits and is the team’s best hitter, with a .269 batting average. Wilmer Flores leads the team in RBI with 59, while Matt Chapman adds a team-high 16 home runs. 

Justin Verlander (R) is the projected starting pitcher for the Giants, and he has a 1-8 record, 4.70 ERA and 1.49 WHIP.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 45-62 record this season and are sitting on the last place of the NL Central. They have a 14-37 road record, and are 42-62 in over/under. They are coming off a 6-5 road victory over the Giants, and are 6-1 in their last 7 games. Under is 6-2 in their last 8 games and are playing the Rockies and the Giants next.

The Pirates have a .230 batting average this season, .300 OBP and .341 slugging percentage. Pittsburgh’s pitching staff has a 3.73 ERA and 1.20 WHIP. Bryan Reynolds leads the Pirates with 91 hits, and a team-high 51 RBI. Isiah Kiner-Falefa is the team’s best hitter with a .265 batting average, while Oneil Cruz leads the team in home runs, with 17.

Bailey Falter (L) is the projected starting pitcher for the Pirates, and he has a 7-5 record, 3.82 ERA and 1.18 WHIP.

Why the San Francisco Giants will win

• The Pirates have lost each of their last seven night games following a road win.
• The Giants have won nine of their last 11 games against NL Central opponents following a home loss.
• The Pirates have failed to cover the run line in six of their last seven night games against National League opponents following a road win.
• The Giants have covered the run line in four of their last five night games against the Pirates following a loss.

Why the Pittsburgh Pirates will win

• The underdogs have won each of the last six games between the Pirates and Giants.
• The Giants have lost each of their last four games as favorites.
• The Giants have failed to cover the run line in each of their last 12 games as home favorites against National League opponents.
• The Pirates have covered the run line in 14 of their last 15 games as underdogs against National League opponents.
• The Pirates have led after 3 innings in each of their last four games against opponents that held a winning record.
• The Pirates have led after 5 innings in 13 of their last 17 games at Oracle Park against National League opponents that held a winning record.

Total Runs Facts

• Each of the last four games between the Pirates and Giants have gone OVER the total runs line.
• Six of the Pirates’ last seven games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in seven of the Giants’ last eight night games against NL Central opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Pirates’ last seven Tuesday games.

Matchup/League Facts

• The Giants rank T1st in the league for home runs allowed this season (93).
• The Giants rank 29th in the league for steals this season (47).
• The Pirates rank 30th in the league for runs scored this season (364).
• The Pirates rank 30th in the league for home runs this season (71).

Pittsburgh Pirates vs San Francisco Giants Prediction

The Giants are 7-3 in their last 10 overall meetings against the Pirates, but the Pirates are 3-2 in their last 5 meetings in San Fran. Over is 4-0 in their last 4 meetings. 

In this Pittsburgh Pirates vs San Francisco Giants Prediction, the Giants are coming as -160 home favorites. The Giantsare rightfully favored, as they have a better overall record, and have been above average at home, while the Pirates have been terrible on the road. Verlander has been terrible for the Giants and has won only one of his nine starts, and he has to face a red-hot Pirates lineup. The Giants have been in a slump lately, and have been terrible against lefties, with 3.1 runs per game and .217 batting average against southpaws, and I certainly cannot back them at this price. The value here lies with the road dog, so give me once again the Pittsburgh Pirates on the road for plus money.