San Francisco (61-67) vs Milwaukee (80-48)
August 22, 2025 at 08:10 PM EDT
The Line: Betting Odds: Milwaukee -1.5 — Over/Under: +8.5
The San Francisco Giants and Milwaukee Brewers meet Friday in MLB action at American Family Field. Here’s a San Francisco Giants vs Milwaukee Brewers Prediction. This article will include a San Francisco Giants vs Milwaukee Brewers Pick.
San Francisco Giants Betting Preview
The San Francisco Giants are 61-67 on the year and play the Cubs, Orioles, and Rockies next. The San Francisco Giants are batting .231 on the season, have a .308 OBP, and a .375 slugging percentage. The San Francisco Giants pitching staff has a 3.75 ERA and a 1.29 WHIP. Heliot Ramos leads the San Francisco Giants with 29 hits and 53 RBI, while Jung Hoo Lee and Willy Adames have combined for 224 hits and 110 RBI.
Carson Whisenhunt gets the ball for the San Francisco Giants, and he is 1-1 with a 5.02 ERA and 12 strikeouts this season. This will be Whisenhunt’s first career game against the Milwaukee Brewers.
Milwaukee Brewers Betting Preview
The Milwaukee Brewers are 80-48 on the year and play the Diamondbacks, Blue Jays, and Phillies next. The Milwaukee Brewers are batting .258 on the season, have a .332 OBP, and a .404 slugging percentage. The Milwaukee Brewers pitching staff has a 3.56 ERA and a 1.23 WHIP. Brice Turang leads the Milwaukee Brewers with 132 hits and 64 RBI while Sal Frelick and Jackson Chourio have combined for 247 hits and 116 RBI.
Jose Quintana gets the ball for the Milwaukee Brewers, and he is 10-4 with a 3.32 ERA and 73 strikeouts this season. Quintana is 2-4 with a 4.46 ERA and 34 strikeouts in his career against the San Francisco Giants.
Why the Milwaukee Brewers will win
The Brewers have won each of their last 10 games against National League opponents that held a losing record.
The Giants have lost each of their last six games against National League opponents following a loss.
The Brewers have covered the run line each of their last nine games against National League opponents that held a losing record.
The Giants have failed to cover the run line in eight of their last nine games against National League opponents after playing the previous day.
The Giants have trailed after 5 innings in five of their last six games against National League opponents.
The Giants have trailed after 3 innings in three of their last four games at American Family Field against National League opponents that held a winning record.
Why the San Francisco Giants will win
The underdogs have won four of the Brewers’ last five games.
The Brewers have lost three of their last four games as home favorites against National League opponents following a road win.
The Giants have covered the run line in each of their last eight Friday games as underdogs against NL Central opponents.
The Brewers have failed to cover the run line in each of their last four games as home favorites against National League opponents following a road win.
The Giants have led after 3 innings in three of their last four games as underdogs against NL Central opponents.
The Brewers have trailed after 5 innings in three of their last four games against National League opponents.
Milwaukee Brewers Player Prop Facts
Christian Yelich has hit a home run in each of the Brewers’ last two night games against opponents that held a losing record.
Andrew Vaughn has recorded at least one hit in each of his last 16 appearances in night games against NL teams that held a losing record.
Jose Quintana has recorded a win in seven of his last eight appearances in night games against NL teams that held a losing record.
Brice Turang has recorded a Double in three of the Brewers’ last four night games.
San Francisco Giants Player Prop Facts
Rafael Devers has hit a home run in three of the Giants’ last five games as road underdogs.
Jung Hoo Lee has recorded at least one hit in each of the Giants’ last 12 night games against NL opponents that held a winning record.
San Francisco Giants vs Milwaukee Brewers Prediction
The Giants have won two games since August 9 and now throw out Whisenhunt, who has allowed 13 hits and eight earned runs in 14.1 innings. The Giants are a tough sell in their current form, and the pitching situation doesn’t help. Quintana has found the fountain of youth at 36 years old, and he’s allowed seven runs in his last 23.1 innings. The Brewers keep racking up the wins overall. This is two teams heading in different directions. I have to roll with the Brewers at home.