San Francisco Giants vs Arizona Diamondbacks Prediction 9/17/2025 Today’s MLB Picks

In this article, we will formulate a Giants vs Diamondbacks Prediction for this MLB game on Wednesday, September 17th at the Chase Field in the third game of this series, with the Dbacks having the 2-0 lead. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 77-75 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 40-34 home record and are 73-70 in over/under They are coming off a 6-5 home victory over the Giants, and are 5-1 in their last 6 games. They are playing the Phillies and the Dodgers next.

The Diamondbacks have a .252 batting average this season, .325 OBP and .436 slugging percentage. Arizona’s pitching staff has a 4.45 ERA and 1.31 WHIP. Geraldo Perdomo leads the Diamondbacks with 161 hits, adding a team-high 97 RBI. He Is also the team’s best hitter with a .290 batting average, while Corbin Carroll leads the team in home runs with 30.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 13-8 record, 5.31 ERA and 1.40 WHIP.

San Francisco Giants Preview

The San Francisco Giants have a 75-76 record this season and are sitting on the third place of the NL West. They have a 37-39 road record and are 72-73 in over/under. They are coming off a 5-6 road defeat by the Dbacks, and have four consecutive losses. Over is 8-3 in their last 11 games and are playing the Dodgers and the Cardinals next.

The Giants have a .237 batting average this season, .312 OBP and .388 Slugging percentage. San Francisco’s pitching staff has a 3.87 ERA and 1.31 WHIP.  Heliot Ramos leads the Giants with 149 hits, while Jung Hoo Lee is the team’s best hitter, with a .262 batting average. Willy Adames leads the team in RBI with 82, adding a team-high 28 home runs.  

Justin Verlander (R) is the projected starting pitcher for the Giants, and he has a 3-10 record, 3.94 ERA and 1.37 WHIP.

San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 17, 2025

• Probable Starting Pitcher: Brandon Pfaadt      Record this season: 13-8      ERA: 5.31
• Home Record: 9-3
• Last 5 against Giants: 0-4

Why the Arizona Diamondbacks will win

• The Giants have lost each of their last seven day games against NL West opponents following a loss.
• The Diamondbacks have won seven of their last eight home games against National League opponents.
• The Giants have failed to cover the run line each of their last four day games against NL West opponents that held a winning record.
• The Diamondbacks have covered the run line in five of their last six games.
• The Diamondbacks have led after 5 innings in each of their last six home games against NL West opponents that held a losing record.
• The Diamondbacks have led after 3 innings in seven of their last eight home day games.
• The Diamondbacks have won the first inning in 12 of their last 13 home games against National League opponents.

• Probable Starting Pitcher: Justin Verlander      Record this season: 3-10      ERA: 3.94
• Road Record: 1-4
• Last 5 against Diamondbacks: 2-2

Why the San Francisco Giants will win

• The Diamondbacks have lost eight of their last nine day games against National League opponents that held a losing record.
• The underdogs have won seven of the Diamondbacks’ last 10 games at Chase Field.
• The Diamondbacks have failed to cover the run line in eight of their last nine day games against National League opponents that held a losing record.
• The Giants have covered the run line in each of their last five games following a road loss.
• The Giants have led after 3 innings in five of their last six road games against NL West opponents.
• The Giants have won the first inning in five of their last six games against opponents that held a winning record.

Total Runs Facts

• Five of the Diamondbacks’ last six games as favorites against the Giants have gone OVER the total runs line.
• Five of the Giants’ last six day games against National League opponents have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Diamondbacks’ last 13 home games against National League opponents.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last four games at Chase Field.

Arizona Diamondbacks Player Prop Facts

• James McCann has hit a home run in three of his last four appearances with his team as a favorite against the Giants.
• Geraldo Perdomo has recorded a Double in three of the Diamondbacks’ last four home games against NL West opponents.
• Brandon Pfaadt has recorded a win in four of his last five home appearances against NL West opponents.
• Brandon Pfaadt has recorded five or more strikeouts in five of his last six appearances in day games.
• Corbin Carroll has recorded at least one hit in each of the Diamondbacks’ last 17 games as favorites.
• Geraldo Perdomo ranks 6th amongst qualified players for On Base Percentage (.393) this season.

San Francisco Giants Player Prop Facts

• Justin Verlander has recorded five or more strikeouts in nine of his last 10 appearances in day games against NL teams that held a winning record.
• Heliot Ramos has recorded at least one hit in each of the Giants’ last 17 Wednesday games.
• Wilmer Flores has hit a home run in two of his last three road appearances against NL West opponents.
• Rafael Devers ranks 9th amongst qualified players for On Base Percentage (.374) this season.

Matchup/League Facts

• The Diamondbacks rank 1st in the league for triples this season (36).
• The Diamondbacks rank 3rd in the league for RBIs this season (736).
• The Giants rank 1st in the league for home runs allowed this season (129).
• The Giants rank 29th in the league for steals this season (65).

Giants vs Diamondbacks Prediction

The Dbacks have won their last three meetings against the Giants, and are 4-2 in their last 6 meetings Arizona. Over is 8-3 in their last 11 meetings.

In this Giants vs Diamondbacks Prediction, both teams are coming at a pickem price. I don’t trust either pitcher in this matchup, as Pfaadt has been unstable at best this season for the Dbacks, and has been in terrible form lately, having given up 4+ runs in three of his last four starts. On the flip side, Verlander has been untrustworthy this season, but he has been lights out lately, having given up only one run in his last three starts. the Giants have the third-best bullpen in baseball and are better against right-handed pitching, so I will take my chances with them on the road in this one.