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San Francisco Giants vs Arizona Diamondbacks Prediction 9/15/2025 Today’s MLB Picks

Sep 14, 2025; Minneapolis, Minnesota, USA; Arizona Diamondbacks center fielder Alek Thomas (5) catches a fly ball hit by Minnesota Twins second base Luke Keaschall (15) in the sixth inning at Target Field. Mandatory Credit: Matt Blewett-Imagn Images

Sep 14, 2025; Minneapolis, Minnesota, USA; Arizona Diamondbacks center fielder Alek Thomas (5) catches a fly ball hit by Minnesota Twins second base Luke Keaschall (15) in the sixth inning at Target Field. Mandatory Credit: Matt Blewett-Imagn Images

MATCHUP San Francisco Giants Arizona Diamondbacks
Team Records 75-75 76-75
Where Chase Field, Phoenix, Arizona
When Monday, September 15, 2025
Time 09:40 PM EDT
TV NBC Sports BA

The San Francisco Giants and Arizona Diamondbacks meet Monday in MLB action at Chase Field. Here’s a San Francisco Giants vs Arizona Diamondbacks Prediction. This article will include a San Francisco Giants vs Arizona Diamondbacks Pick.

San Francisco Giants Betting Preview

The San Francisco Giants are 75-74 on the year and play the Dodgers, Cardinals, and Rockies next. The San Francisco Giants are batting .238 on the season, have a .313 OBP, and a .390 slugging percentage. The San Francisco Giants pitching staff has a 3.84 ERA and a 1.30 WHIP. Heliot Ramos leads the San Francisco Giants with 148 hits and 61 RBI, while Jung Hoo Lee and Willy Adames have combined for 265 hits and 134 RBI.

Kai-Wei Teng gets the ball for the San Francisco Giants, and he is 2-4 with a 7.54 ERA and 28 strikeouts this season. This will be Teng’s second career game against the Arizona Diamondbacks.

Arizona Diamondbacks Betting Preview

The Arizona Diamondbacks are 75-75 on the year and play the Phillies, Dodgers, and Padres next. The Arizona Diamondbacks are batting .250 on the season, have a .323 OBP, and a .434 slugging percentage. The Arizona Diamondbacks pitching staff has a 4.47 ERA and a 1.32 WHIP. Geraldo Perdomo leads the Arizona Diamondbacks with 157 hits and 95 RBI while Corbin Carroll and Lourdes Gurriel Jr. have combined for 258 hits and 156 RBI.

Zac Gallen gets the ball for the Arizona Diamondbacks, and he is 11-14 with a 4.84 ERA and 157 strikeouts this season. Gallen is 7-6 with a 3.94 ERA and 114 strikeouts in his career against the San Francisco Giants.

San Francisco Giants @ Arizona Diamondbacks Betting Trends: September 15, 2025

Why the Arizona Diamondbacks will win

Why the San Francisco Giants will win

Total Runs Facts

Arizona Diamondbacks Player Prop Facts

San Francisco Giants Player Prop Facts

Matchup/League Facts

San Francisco Giants vs Arizona Diamondbacks Prediction

The Giants are arguably the better team playing the better ball, but I can’t get behind Teng, who has allowed 26 hits and 19 earned runs in his last 22.2 innings. In 16 road innings, Teng has a 7.31 ERA and .288 allowed batting average. No, thanks. Gallen is having a down year, but we know what he’s capable of when he’s right, as he’s somebody who has earned CY Young votes in his career. Gallen has also allowed just 11 hits and 5 runs in his last 18.2 innings. At home and a chance to gain ground in the NL wild card, this should be a win for the Diamondbacks with their ace on the bump.

Randy Chambers's Pick: Arizona Diamondbacks

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