San Diego (55-49) vs St. Louis (54-51)
July 26, 2025 at 07:15 PM EDT
The Line: Betting Odds: St. Louis -1.5 — Over/Under: +9
The San Diego Padres and St. Louis Cardinals meet Saturday in MLB action at Busch Stadium. Here’s a San Diego Padres vs St. Louis Cardinals Prediction. This article will include a San Diego Padres vs St. Louis Cardinals Pick.
San Diego Padres Betting Preview
The San Diego Padres are 55-49 on the year and play the Mets, Cardinals, and Diamondbacks next. The San Diego Padres are batting .247 on the season, have a .314 OBP, and a .376 slugging percentage. The San Diego Padres pitching staff has a 3.62 ERA and a 1.24 WHIP. Manny Machado leads the San Diego Padres with 116 hits and 63 RBI, while Luis Arraez and Fernando Tatis Jr. have combined for 218 hits and 81 RBI.
Randy Vasquez gets the ball for the San Diego Padres, and he is 3-4 with a 3.73 ERA and 50 strikeouts this season. This will be Vasquez’s second career game against the St. Louis Cardinals.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 54-51 on the year and play the Marlins, Padres, and Dodgers next. The St. Louis Cardinals are batting .253 on the season, have a .322 OBP, and a .394 slugging percentage. The St. Louis Cardinals pitching staff has a 4.19 ERA and a 1.29 WHIP. Brendan Donovan leads the St. Louis Cardinals with 110 hits and 42 RBI while Willson Contreras and Masyn Winn have combined for 192 hits and 97 RBI.
Matthew Liberatore gets the ball for the St. Louis Cardinals, and he is 6-7 with a 4.13 ERA and 80 strikeouts this season. Liberatore is 0-1 with a 3.38 ERA and 6 strikeouts in his career against the San Diego Padres.
Why the St. Louis Cardinals will win
- The Padres have lost each of their last eight games at Busch Stadium against teams that held a winning record.
- The Cardinals have won each of their last seven home games against the Padres following a home win.
- The Padres have failed to cover the run line in each of their last four games at Busch Stadium.
- The home team has covered the run line in each of the Cardinals’ last four games.
- The Cardinals have led after 3 innings in each of their last three night games against NL West opponents that held a winning record.
- The Padres have trailed after 5 innings in each of their last four games.
Why the San Diego Padres will win
- The Cardinals have lost each of their last four games as favorites against National League opponents following a win.
- The Padres have won four of their last five games as road underdogs against NL Central opponents following a road loss.
- The Cardinals have failed to cover the run line in each of their last six games as favorites against National League opponents following a home win.
- The Padres have covered the run line in nine of their last 10 games as underdogs against NL Central opponents.
St. Louis Cardinals Player Prop Facts
- Willson Contreras has recorded at least one hit in each of the Cardinals’ last 10 night games.
- Lars Nootbaar has hit a home run in each of his last two appearances at Busch Stadium against NL opponents that held a winning record.
- Willson Contreras has recorded a Double in each of the Cardinals’ last five games.
San Diego Padres Player Prop Facts
- Fernando Tatis Jr. has recorded at least one hit in each of the Padres’ last 10 games against opponents that held a winning record.
- Manny Machado has hit a home run in four of the Padres’ last seven games as road underdogs against NL Central opponents.
- Xander Bogaerts has recorded at least one Double in five of the Padres’ last six games as road underdogs.
San Diego Padres vs St. Louis Cardinals Prediction
The padres have lost four straight games due to an offense that can’t string together anything. So, while Vasquez has been decent, it doesn’t matter if he gets no run support. Also, Vasquez has a 4.34 ERA and .261 allowed batting average in 45.2 road innings. Liberatore has been a mess for much of the season, and he’s allowed eight runs in his last eight innings. Still, the Cardinals continue to be a surprise team that’s three games above a .500 record and have value in spots like this. The Padres need to get their act together. Give me the Cards at home.