San Diego (55-47) vs St. Louis (52-51)
July 24, 2025 at 07:45 PM EDT
The Line: Betting Odds: St. Louis -1.5 — Over/Under: +8.5
The San Diego Padres and St. Louis Cardinals meet Thursday in MLB action at Busch Stadium. Here’s a San Diego Padres vs St. Louis Cardinals Prediction. This article will include a San Diego Padres vs St. Louis Cardinals Pick.
San Diego Padres Betting Preview
The San Diego Padres are 55-47 on the year and play the Mets, Cardinals, and Diamondbacks next. The San Diego Padres are batting .245 on the season, have a .314 OBP, and a .374 slugging percentage. The San Diego Padres pitching staff has a 3.58 ERA and a 1.23 WHIP. Luis Arraez leads the San Diego Padres with 111 hits and 37 RBI, while Manny Machado and Fernando Tatis Jr. have combined for 210 hits and 103 RBI.
Yu Darvish gets the ball for the San Diego Padres, and he is 0-2 with a 6.08 ERA and 8 strikeouts this season. Darvish is 2-4 with a 3.20 ERA and 68 strikeouts in his career against the St. Louis Cardinals.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 52-51 on the year and play the Marlins, Padres, and Dodgers next. The St. Louis Cardinals are batting .252 on the season, have a .321 OBP, and a .393 slugging percentage. The St. Louis Cardinals’ pitching staff has a 4.21 ERA and a 1.29 WHIP. Brendan Donovan leads the St. Louis Cardinals with 107 hits and 39 RBI, while Masyn Winn and Willson Contreras have combined for 187 hits and 91 RBI.
Sonny Gray gets the ball for the St. Louis Cardinals, and he is 9-4 with a 4.04 ERA and 123 strikeouts this season. Gray is 3-0 with a 1.59 ERA and 19 strikeouts in his career against the San Diego Padres.
Why the St. Louis Cardinals will win
The Padres have lost each of their last six games at Busch Stadium against teams that held a winning record.
The Cardinals have won each of their last five night games against NL West opponents following a loss.
The Cardinals have covered the run line in 13 of their last 14 night games against NL West opponents following a loss.
The Padres have failed to cover the run line in four of their last five games against the Cardinals following a loss.
The Padres have trailed after 5 innings in three of their last four games against National League opponents that held a winning record.
Why the San Diego Padres will win
The Padres have won each of their last seven games against NL Central opponents following a loss.
The Cardinals have lost four of their last five games as favorites against National League opponents.
The Padres have covered the run line in each of their last 10 night games at Busch Stadium following a loss.
The Cardinals have failed to cover the run line each of their last six Thursday night games against teams that held a winning record.
The Padres have led after 3 innings in four of their last five games against the Cardinals.
St. Louis Cardinals Player Prop Facts
Masyn Winn has recorded at least one hit in each of the Cardinals’ last 13 games as favorites against NL West opponents.
Lars Nootbaar has hit a home run in each of his last two appearances at Busch Stadium against NL opponents that held a winning record.
Willson Contreras has recorded a Double in five of the Cardinals’ last six games as favorites.
Sonny Gray has recorded a win in each of his three previous appearances against the Padres.
Victor Scott II ranks T9th in the league in Steals (25) this season.
San Diego Padres Player Prop Facts
Manny Machado has hit a home run in six of the Padres’ last seven Thursday games against NL Central opponents that held a winning record.
Yu Darvish has recorded five or more strikeouts in 17 of his 19 previous road appearances against NL Central opponents.
Xander Bogaerts has recorded at least one hit in each of the Padres’ last eight games as road underdogs.
Yu Darvish has recorded a win in five of his last six road appearances against opponents that held a winning record.
Xander Bogaerts has recorded at least one Double in four of the Padres’ last five games as road underdogs.
Manny Machado ranks T8th in the league in Hits (111) this season.
San Diego Padres vs St. Louis Cardinals Prediction
We know what Darvish is capable of when he’s right, but he’s pitched just 13.1 innings this season and hasn’t looked good. Darvish has allowed 13 hits and nine runs, and he has seven walks with eight strikeouts. Gray went from looking like an all-star to allowing 24 hits and 15 earned runs in his last 17.2 innings. Gray has seen his ERA just to over four on the season due to what’s been a rough July. The Cardinals’ offense is due for a breakout performance. I’m not excited about this pitching matchup. Give me the over on Thursday night.