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San Diego Padres vs Seattle Mariners Prediction 8/26/2025 Today’s MLB Picks

Aug 25, 2025; Seattle, Washington, USA; Seattle Mariners catcher Cal Raleigh (29) holds the “Vedder Cup” trophy for the winning the season series against the San Diego Padres following a victory Padres at T-Mobile Park. The “Vedder Cup” is named after Pearl Jam frontman Eddie Vedder. Mandatory Credit: Joe Nicholson-Imagn Images

Aug 25, 2025; Seattle, Washington, USA; Seattle Mariners catcher Cal Raleigh (29) holds the “Vedder Cup” trophy for the winning the season series against the San Diego Padres following a victory Padres at T-Mobile Park. The “Vedder Cup” is named after Pearl Jam frontman Eddie Vedder. Mandatory Credit: Joe Nicholson-Imagn Images

MATCHUP San Diego Padres Seattle Mariners
Team Records 74-58 71-61
Where T-Mobile Park, Seattle, Washington
When Tuesday, August 26, 2025
Time 09:40 PM EDT
TV Root Sports NW

The San Diego Padres and Seattle Mariners meet Tuesday in MLB action at T-Mobile Park. Here’s a San Diego Padres vs Seattle Mariners Prediction. This article will include a San Diego Padres vs Seattle Mariners Pick.

San Diego Padres Betting Preview

The San Diego Padres are 74-58 on the year and play the Twins, Orioles, and Rockies next. The San Diego Padres are batting .251 on the season, have a .321 OBP, and a .385 slugging percentage. The San Diego Padres pitching staff has a 3.57 ERA and a 1.19 WHIP. Luis Arraez leads the San Diego Padres with 147 hits and 48 RBI, while Manny Machado and Fernando Tatis Jr. have combined for 276 hits and 132 RBI.

Dylan Cease gets the ball for the San Diego Padres, and he is 6-11 with a 4.71 ERA and 178 strikeouts this season. This will be Cease’s second career game against the Seattle Mariners.

Seattle Mariners Betting Preview

The Seattle Mariners are 71-61 on the year and play the Guardians, Rays, and Braves next. The Seattle Mariners are batting .242 on the season, have a .318 OBP, and a .411 slugging percentage. The Seattle Mariners pitching staff has a 3.96 ERA and a 1.26 WHIP. Julio Rodriguez leads the Seattle Mariners with 140 hits and 73 RBI while J.P. Crawford and Cal Raleigh have combined for 245 hits and 153 RBI.

Luis Castillo gets the ball for the Seattle Mariners, and he is 8-7 with a 3.57 ERA and 127 strikeouts this season. Castillo is 3-3 with a 3.13 ERA and 49 strikeouts in his career against the San Diego Padres.

Why the Seattle Mariners will win

Why the San Diego Padres will win

Seattle Mariners Player Prop Facts

San Diego Padres Player Prop Facts

San Diego Padres vs Seattle Mariners Prediction

We have two capable offenses and two pitchers who can get rocked from time to time. Cease hasn’t been good on the road through 65.1 innings, as he has a 5.65 ERA and .255 allowed batting average. Castillo has allowed 28 hits and 13 runs in his last 19.1 innings. We saw 15 runs between the Mariners and Padres last night and I expect some runs in this spot as well. Give me the over.

Randy Chambers's Pick: Over 8

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