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San Diego Padres vs Seattle Mariners Prediction 8/25/2025 Today’s MLB Picks

May 18, 2025; San Diego, California, USA; Seattle Mariners second baseman Leo Rivas (76) throws over San Diego Padres catcher Elias Diaz (17) as he turns a double play during the eighth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

May 18, 2025; San Diego, California, USA; Seattle Mariners second baseman Leo Rivas (76) throws over San Diego Padres catcher Elias Diaz (17) as he turns a double play during the eighth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP San Diego Padres Seattle Mariners
Team Records 74-58 71-61
Where T-Mobile Park, Seattle, Washington
When Monday, August 25, 2025
Time 09:40 PM EDT
TV Root Sports NW

In this article, we will formulate a Padres vs Mariners Prediction for this MLB game on Monday, August 25th at the T-Mobile Park in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Seattle Mariners Preview

The Seattle Mariners have a 70-61 record this season and are sitting on the second place of the AL West. The Mariners have a 39-26 home record and are 70-55 in over/under. They are coming off a 11-4 home victory over the Athletics, and are 2-6 in their last 8 games. Over is 6-3 in their last 9 games and they are playing the Rays and the Guardians next.

The Mariners have a .241 batting average this season, .317 OBP and .410 Slugging percentage. Seattle’s pitching staff has a 3.95 ERA and 1.26 WHIP. Julio Rodriguez leads the Mariners in hits with 139, while JP Crawford is the team’s best hitter with a .262 batting average. Cal Raleigh leads the team both in RBI with 106, and in home runs with 49.

Bryce Miller (R) is the projected starting pitcher for the Mariners, and he has a 2-5 record, 5.87 ERA and 1.51 WHIP.

San Diego Padres Preview

The San Diego Padres have a 74-57 record this season and are sitting on the second place of the NL West. They have a 31-35 road record, and are 54-73 in over/under. The Padres are coming off a 2-8 home defeat by the Dodgers, which ended their previous five-game winning streak. They are playing the Twins and the Orioles next.

The Padres have a .251 batting average this season, .321 OBP and .383 Slugging percentage. San Diego’s pitching staff has a 3.53 ERA and 1.19 WHIP. Manny Machado leads the Padres with 147 hits and is the team’s best hitter with a .292 batting average. He also leads the team in RBI, with 78, and in home runs, with 21.

JP Sears (R) is the projected starting pitcher for the Padres, and he has an 8-10 record, 4.94 ERA and 1.29 WHIP.

Why the Seattle Mariners will win

Why the San Diego Padres will win

Total Runs Facts

Padres vs Mariners Prediction

The Mariners are 8-1 in their last 9 head-to-head meetings against the Padres, and are 3-1 their last 4 meetings in Seattle. Under is 6-2-1 in their last 9 meetings.

In this Padres vs Mariners Prediction, the Mariners are coming as -125 home favorites. I don’t trust either pitcher in this matchup, as they both have been shaky at best, and not in the best current form. Miller has not been himself this season, and he has been lit up lately, having given up 19 runs in 18 innings pitched across his last four starts. The Padres have the best bullpen in basketball for come after Sears, and the Mariners are terrible against left-handed pitching, so I like the chances with the road dog in this one. Take the San Diego Padres on the moneyline for plus money.

Nikos Lagouretos's Pick: San Diego Padres +105

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