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San Diego Padres vs San Francisco Giants Prediction 9/13/2026 Today’s MLB Picks

Sep 12, 2026; San Francisco, California, USA;  San Francisco Giants starting pitcher Cesar Perdomo (with ball) gets removed for a reliever during the sixth inning against the San Diego Padres at Oracle Park.  Mandatory Credit: D. Ross Cameron-Imagn Images

Sep 12, 2026; San Francisco, California, USA; San Francisco Giants starting pitcher Cesar Perdomo (with ball) gets removed for a reliever during the sixth inning against the San Diego Padres at Oracle Park. Mandatory Credit: D. Ross Cameron-Imagn Images

MATCHUP San Diego Padres San Francisco Giants
Team Records 80-68 62-87
Spread -1.5 134 +1.5 -162
Moneyline -132 +110
Total Over 7 (-110) Under 7 (-110)
Where Oracle Park, San Francisco, California
When Sunday, September 13, 2026
Time 07:20 PM EDT
TV Peacock
The San Diego Padres and San Francisco Giants meet Sunday in MLB action at Oracle Park. Here’s a San Diego Padres vs. San Francisco Giants Prediction. This article will include a San Diego Padres vs San Francisco Giants Pick.

San Diego Padres Betting Preview


The San Diego Padres are 80-68 this year and play the Rockies and Marlins next. The San Diego Padres are batting .239 on the season, have a .316 OBP, and have a .390 slugging percentage. The San Diego Padres’ pitching staff has a 3.91 ERA and a 1.28 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 164 hits and 73 RBI, while Jackson Merrill and Manny Machado have combined for 257 hits and 160 RBI.

Nick Pivetta gets the ball for the San Diego Padres, and he is 2-2 with a 3.43 ERA and 26 strikeouts this season. Pivetta is 5-1 with a 3.83 ERA and 52 strikeouts in his career against the San Francisco Giants.

San Francisco Giants Betting Preview


The San Francisco Giants are 62-87 on the year and play the Cardinals and Dodgers next. The San Francisco Giants are batting .247 on the season, have a .308 OBP, and have a .408 slugging percentage. The San Francisco Giants’ pitching staff has a 4.37 ERA and a 1.37 WHIP. Rafael Devers leads the San Francisco Giants with 144 hits and 98 RBI, while Jung Hoo Lee and Willy Adames have combined for 250 hits and 106 RBI.

Logan Webb gets the ball for the San Francisco Giants, and he is 8-8 with a 4.10 ERA and 127 strikeouts this season. Webb is 5-6 with a 3.60 ERA and 90 strikeouts in his career against the San Diego Padres.

Why the San Francisco Giants will win

Why the San Diego Padres will win

Total Runs Facts

San Francisco Giants Player Prop Facts

San Diego Padres Player Prop Facts

San Diego Padres vs San Francisco Giants Prediction


I usually blindly back Webb at Oracle as he’s been fantastic in this park over his career. Plus, money is worth a look. The problem is the Giants stink, and the Padres are fighting for a playoff spot. Pivetta is also a solid pitcher in his own right with above-average stuff, and he has a 3.43 ERA and 0.95 WHIP through 21 innings. Even though Webb isn’t an easy matchup, the Padres need to take advantage of games against bad teams to inch closer to the postseason. Give me the Padres.

Randy Chambers's Pick: San Diego Padres

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