| MATCHUP | San Diego Padres | San Francisco Giants |
|---|---|---|
| Team Records | 20-14 | 14-21 |
| Spread | +1.5 -194 | -1.5 159 |
| Moneyline | +109 | -131 |
| Total | Over 7.5 (-105) | Under 7.5 (-115) |
| Where | Oracle Park, San Francisco, California | |
| When | Tuesday, May 5, 2026 | |
| Time | 09:45 PM EDT | |
| TV | MLB.TV | |
The San Diego Padres and the San Francisco Giants meet Saturday in MLB action from Oracle Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. San Francisco Giants prediction.
Starting Pitching Matchup
The San Diego Padres will send out Walker Buehler for the start here and Buehler is 1-2 with a 5.40 ERA and 24 strikeouts this season. In his last five starts against the Giants, Buehler is 1-3 with a 4.62 ERA and 27 strikeouts. Logan Webb will start here and is 2-3 with a 4.30 ERA and 38 strikeouts this season. In his last five starts against the Padres, Webb is 1-3 with a 4.60 ERA and 25 strikeouts.
San Diego Padres Recap
The San Diego Padres come into this game looking to bounce back from a 3-2 loss at the hands of the Giants on Monday to fall to 20-14 this season. After this series, the Padres will head home for a series against the St. Louis Cardinals.
Padres Lose 6 Of Last 8
Jackson Merrill has 28 hits with 6 doubles, 4 home runs and 16 RBIs while Ramon Laureano has 29 hits with 4 doubles, 2 triples, 5 home runs and 19 RBIs as well on the year. Fernando Tatis Jr. has 31 hits with 4 doubles and 13 RBIs and Xander Bogaerts has 32 hits with 2 doubles, 5 home runs and 18 RBIs. Manny Machado also has 25 hits with 4 doubles, 5 home runs and 18 RBIs as well on the year.
San Francisco Giants Recap
The San Francisco Giants come into this game looking to build on their win over the Padres from Monday to improve to 14-21 on the year. After this series, the Giants will square off against the Pittsburgh Pirates at home.
Giants Snap Six-Game Skid
Luis Arraez has 42 hits with 7 doubles, 2 triples and 11 RBIs while Willy Adames has 27 hits with 11 doubles, 3 home runs and 6 RBIs along with 45 strikeouts. Matt Chapman has 32 hits with 6 doubles, a triple, a home run and 12 RBIs and Jung Hoo Lee has 34 hits with 8 doubles and 11 RBIs. Heliot Ramos has 34 hits with 8 doubles, 3 home runs and 15 RBIs this season. Rafael Devers also has 29 hits with 6 doubles, 2 home runs and 14 RBIs but also has 43 strikeouts this season.
San Diego Padres @ San Francisco Giants Betting Trends: May 5, 2026
- Probable Starting Pitcher: Logan Webb Record this season: 2-3 ERA: 4.30
- Home Record: 0-2
- Last 5 against Padres: 1-3
Why the San Francisco Giants will win
- The home team has won each of the Giants’ last nine games.
- The Padres have lost five of their last six games.
- The Padres have failed to cover the run line in each of their last six games.
- The Giants have covered the run line in each of their last six night games against NL West opponents.
- The Padres have trailed after 3 innings in seven of their last eight games against National League opponents.
- The Giants have led after 5 innings in each of their last four games as favorites against NL West opponents.
- The Giants have won the first inning in four of their last five games as favorites against NL West opponents.
- Probable Starting Pitcher: Walker Buehler Record this season: 1-2 ERA: 5.40
- Road Record: 0-1
- Last 5 against Giants: 0-4
Why the San Diego Padres will win
- The Padres have won each of their last six road games following a loss.
- The Giants have lost 20 of their last 28 games as favorites against the Padres following a win.
- The Padres have covered the run line in each of their last 14 games as road underdogs against the Giants.
- The Giants have failed to cover the run line in each of their last six games as home favorites against the Padres following a win.
- The Giants have trailed after 3 innings in four of their last five home games.
- The Giants have trailed after 5 innings in eight of their last nine games as favorites.
Total Runs Facts
- Each of the Giants’ last six home games against NL West opponents have gone UNDER the total runs line.
- Five of the Padres’ last six games as underdogs against the Giants have gone UNDER the total runs line.
- The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Padres’ last 10 games as underdogs.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Giants’ last seven games as favorites against NL West opponents.
San Francisco Giants Player Prop Facts
- Logan Webb has recorded a win in four of his last five appearances with the Giants as favorites against NL West opponents.
- Logan Webb has recorded six or more strikeouts in six of his last eight appearances with the Giants as home favorites against NL West opponents.
- Rafael Devers has recorded at least one hit in each of the Giants’ last eight games as favorites.
- Casey Schmitt has hit a home run in each of the Giants’ last three home games.
- Luis Arraez ranks T8th in the league in Hits (42) this season.
San Diego Padres Player Prop Facts
- Luis Campusano has hit a home run in each of his last three appearances against NL West opponents.
- Jackson Merrill has recorded at least one hit in each of his last seven appearances against the Giants.
- Fernando Tatis Jr. ranks 9th in the league in Steals (9) this season.
Matchup/League Facts
- The Giants rank 30th in the league for runs scored this season (109).
- The Giants rank 30th in the league for home runs this season (20).
- The Padres rank 29th in the league for hits this season (258).
- The Padres rank 27th in the league for batting average this season (.230).
San Diego Padres vs. San Francisco Giants Prediction
I’m leaning towards the Giants in this one. It’s not a game I’m rushing to bet because both sides are having trouble finding offense right now, but I think Logan Webb is the significantly more trustworthy starting pitching option in this game and I think that he gets enough support to hold it down at home as he’s been far better at Oracle Park for the majority of his career. Buehler can be very hit or miss and I think the Padres fall flat on Tuesday. Give me the Giants.