San Diego Padres vs Milwaukee Brewers Prediction 6/6/25 MLB Picks

In this article, we will formulate a Padres vs Brewers prediction for this MLB game on Friday, June 6, at American Family Field in Milwaukee, Wisconsin. Let’s take a look at the prediction for this MLB matchup.

San Diego Padres Betting Preview

The San Diego Padres (35-26, 15-16 Away) are unbeaten in the last four series. The Padres were on a three-series win streak and opened the one against the San Francisco Giants with a pair of wins, but the Giants responded and won the next two to earn a split. In the latest 3-2 defeat, Manny Machado drove in both RBIs for San Diego, while Dylan Cease took the loss after allowing three runs on five hits with seven strikeouts and three walks in 5.0 innings. 

This season, the Padres average 4.15 runs per game (19th in the MLB) on a .249/.314/.380 triple-slash. When it comes to pitching, the Padres’ staff has a 3.55 ERA (9th) and 1.20 WHIP (9th). Gavin Sheets leads the Padres with a .263 batting average, 11 home runs, and 38 RBI this season.

Randy Vasquez will take the mound for the Padres on Friday. The 26-year-old right-hander has a 3-4 record in 12 starts this year with a 3.99 ERA and 1.47 WHIP in 58.2 innings.

Milwaukee Brewers Betting Preview

The Milwaukee Brewers (34-29, 18-10 Home) are in even better form than San Diego, as they are without a loss in the previous five series. The Brewers beat the Orioles, split with the Pirates, swept the Red Sox and Phillies, and defeated the Guardians. In the rubber match on Wednesday, Milwaukee won 9-1. Isaac Collins led the offense with a three-run homer, while Quinn Priester got the win after allowing one run on two hits with four strikeouts and three walks in 5.0 innings. 

This year, the Brewers average 4.57 runs per game (9th in the MLB) on a .239/.315/.368 triple-slash. When it comes to pitching, the Brewers’ staff has a 3.91 ERA (15th) and 1.31 WHIP (19th). Christian Yelich leads the Brewers with a .237 batting average, 13 home runs, and 41 RBI this season.

The projected starting pitcher for the Brewers is Chad Patrick, who is 3-4 in 12 starts this season, with a 2.97 ERA and 1.21 WHIP in 63.2 innings.

Total Runs Facts

• Each of the last four games between the Padres and Brewers have gone OVER the total runs line.
• Five of the Padres’ last six games as underdogs have gone UNDER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Brewers’ last eight games against National League opponents.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in nine of the Padres’ last 11 games as underdogs.

Matchup/League Facts

• The Brewers rank 25th in the league for triples this season (5).
• The Brewers rank 25th in the league for slugging percentage this season (.368).
• The Padres rank 5th in the league for opponent batting average this season (.226).
• The Padres rank 25th in the league for home runs this season (54).

Padres vs Brewers Prediction

The teams have traded victories in the past couple of years, each recording five in the last ten H2H encounters. It’s going to be a tight affair, and I am not sure who will end up victorious, but given the recent H2H duels, we should expect runs. Nine of the last ten H2H duels went Over, and I am backing another one here. Randy Vasquez and Chad Patrick have been solid this season, but Vasquez did allow multiple runs in each of his last three starts. Chad Patrick, on the other hand, surrendered multiple runs in seven of his previous nine starts. I am looking for 5+ runs in the opening five innings. Back the Over.