San Diego Padres vs Chicago White Sox Prediction 9/20/2025 Today’s MLB Picks

Chris Ruffolo

1 day ago

Sep 13, 2025; San Diego, California, USA; San Diego Padres right fielder Fernando Tatis Jr. (23) hits a broken bat single during the sixth inning against the Colorado Rockies at Petco Park. Mandatory Credit: David Frerker-Imagn Images

San Diego (83-71) vs Chicago (58-96)

September 20, 2025 at 07:10 PM EDT

The Line: Betting Odds: Chicago +155 — Over/Under: +8.5

The San Diego Padres and the Chicago White Sox meet Saturday in MLB action from Rate Field. We will look at this from a betting perspective and determine the best bets for this game. Here’s a San Diego Padres vs. Chicago White Sox prediction.

Starting Pitching Matchup

The San Diego Padres will send out Yu Darvish here and Darvish is 4-5 with a 5.63 ERA and 60 strikeouts this season. In his last five starts against the White Sox, Darvish is 2-1 with a 2.51 ERA and 32 strikeouts. Yoendrys Gomez will start this one for the White Sox and is 3-2 with a 4.91 ERA and 49 strikeouts this season. This will be Gomez’s first career start against the Padres.

San Diego Padres Recap

The San Diego Padres come into this game looking to rebound from a 4-3 loss at the hands of the White Sox in Friday’s series opener to sit at 83-71 this season. After this series, the Padres will head home for a series against the Milwaukee Brewers.

Padres Drop Back-To-Back Games

Manny Machado has 164 hits including a team-high 33 doubles, 26 home runs, 92 RBIs and 14 stolen bases while Fernando Tatis Jr. has 153 hits with 22 home runs and 65 RBIs along with 30 stolen bases of his own this season. Luis Arraez has added 170 hits with 29 doubles, 4 triples, 7 home runs and 57 RBIs while Jackson Merrill’s added 107 hits with 14 home runs and 61 RBIs as well. Xander Bogaerts also has 29 doubles and 20 stolen bases as well this season. Gavin Sheets also has 28 doubles, 19 home runs and 68 RBIs as well this season.

Chicago White Sox Recap

The Chicago White Sox come into this game looking to add on to their win over the Padres from Friday’s matchup to sit at 58-96 this season. After this series, the White Sox will head on the road for a series against the New York Yankees.

White Sox Snap Six-Game Losing Streak

Lenyn Sosa has 128 hits including 18 doubles, 20 home runs and 70 RBIs. Andrew Benintendi has 101 hits including 16 doubles, 20 home runs, 62 RBIs and a .240 batting average while Miguel Vargas has 108 hits, 31 doubles, 15 home runs and 55 RBIs. Brooks Baldwin has also added 31 RBIs while Luis Robert Jr. has a team-high 33 stolen bases along with 53 RBIs so far this season. Chase Meidroth has added 111 hits with 13 stolen bases as well as 15 doubles this season.

San Diego Padres @ the Chicago White Sox Betting Trends: September 20, 2025

Probable Starting Pitcher: Yoendrys Gomez Record this season: 3-2 ERA: 4.91
Home Record: 2-1
Last 5 against Padres: 0-0

Why the Chicago White Sox will win

The Padres have lost each of their last four games as favorites against American League opponents.
The White Sox have won four of their last five games as home underdogs against NL West opponents.
The White Sox have covered the run line in each of their last seven home games following a win.
The Padres have failed to cover the run line in nine of their last 10 games as road favorites against American League opponents.
The Padres have trailed after 5 innings in each of their last 10 road games against American League opponents.
The Padres have trailed after 3 innings in five of their last six games against American League opponents.
The White Sox have won the first inning in each of their last four night games.

Probable Starting Pitcher: Yu Darvish Record this season: 4-5 ERA: 5.63
Road Record: 1-3
Last 5 against White Sox: 2-1

Why the San Diego Padres will win

The White Sox have lost each of their last 12 Saturday night games against teams that held a winning record.
The Padres have won each of their last nine Saturday games against AL Central opponents.
The White Sox have failed to cover the run line each of their last 12 Saturday night games against teams that held a winning record.
The Padres have covered the run line in each of their last eight Saturday games against AL Central opponents.
The Padres have led after 3 innings in six of their last seven games against opponents that held a losing record.
The White Sox have trailed after 5 innings in three of their last four night games against opponents that held a winning record.

Total Runs Facts

Each of the White Sox’s last seven games as underdogs have gone UNDER the total runs line.
Seven of the Padres’ last eight games as favorites against the White Sox have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last eight home games.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last seven games.

Chicago White Sox Player Prop Facts

Miguel Vargas has hit a home run in each of the White Sox’s last two games against the Padres.
Andrew Benintendi has recorded at least one hit in each of his last 11 Saturday appearances at Rate Field.

San Diego Padres Player Prop Facts

Elias Diaz has hit a home run in each of his last two appearances with his team as a favorite against the White Sox.
Yu Darvish has recorded six or more strikeouts in each of his last seven appearances against AL opponents that held a losing record.
Xander Bogaerts has recorded at least one hit in each of his last 12 appearances in night games against AL Central teams that held a losing record.
Xander Bogaerts has recorded a Double in each of his last three road appearances against opponents that held a losing record.
Luis Arraez ranks T4th in the league in Hits (170) this season.

Matchup/League Facts

The White Sox rank 29th in the league for walks allowed this season (567).
The White Sox rank 28th in the league for slugging percentage this season (.373).
The Padres rank 1st in the league for opponent batting average this season (.226).
The Padres rank 1st in the league for hits allowed this season (1139).