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San Diego Padres vs Chicago Cubs Prediction 4/6/25 MLB Picks

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Chicago Cubs (7-4) vs San Diego Padres (7-2)

Game Info: Sunday, April 6, 2025 at 2:20 pm (Wrigley Field)

The Line: Betting Odds: Chicago Cubs -145 / San Diego Padres +114 — Over/Under: 7.5

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In this article we will formulate a San Diego Padres vs Chicago Cubs prediction for this MLB game on Sunday, April 6th at Wrigley Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

San Diego Padres Betting Preview

The San Diego Padres are 7-2 this year after they lost game two in this series by a score of 7-1 on Saturday. San Diego allowed the first seven runs in the game, but they did score in the seventh inning to avoid the shutout. The Padres recorded eight hits and committed two errors in the game, while they were led by Tatis Jr, who went 1-4 with one RBI in the loss. San Diego started Pivetta, who allowed six hits and three earned runs over 3.0 innings, while Cruz and Jacob allowed two earned runs each in relief. 

Prior to this series, the Padres swept the Guardians in three games and swept the Braves in four games. The San Diego pitching staff has a 2.28 ERA with a 1.09 WHIP and a .178 opponent batting average, while their offense has scored 38 runs with a .279 batting average and a .344 on base percentage this season. Jackson Merrill has led San Diego with two home runs and eight RBIs, while Fernando Tatis has added one home run and six RBIs this year. The projected starting pitcher for San Diego is Kyle Hart, who is 1-0 with a 3.60 ERA and a 1.20 WHIP over 5.0 innings pitched this year. 

Chicago Cubs Betting Preview

The Chicago Cubs are 7-4 this season after they won games one and two in this series by scores of 7-1 and 3-1. In the game two win, Chicago took an early 2-0 lead in the second inning and they were able to cruise to an easy win the rest of the way. The Cubs recorded 11 hits in the game and they were led by Kelly, who went 2-3 with one home run and four RBIs in the win. Chicago started Boyd, who allowed just five hits over 6.0 innings in the win, while Pearson allowed three hits and one earned run in one relief inning. 

Prior to this series, the Cubs swept the Athletics in three games and split four games with the Diamondbacks. The Chicago pitching staff has a 4.36 ERA with a 1.42 WHIP and a .263 opponent batting average, while the offense has scored 70 runs with a .249 batting average and a .349 on base percentage this season. Kyle Tucker has led Chicago with four home runs and 12 RBIs, while Seiya Suzuki has added four home runs and 11 RBIs this year. The projected starting pitcher for Chicago is Ben Brown, who is 1-1 with a 5.87 ERA and a 1.96 WHIP over 7.2 innings pitched this season. 

Why the Padres will beat the Cubs 

Total Runs Facts

Chicago Cubs Player Prop Facts

San Diego Padres Player Prop Facts

San Diego Padres vs Chicago Cubs Prediction 

San Diego started the season with seven straight wins, but they have been outscored 10-2 in the first two games of this series and will try to avoid being swept here. Chicago has won five games in a row and they have scored at least seven runs four of those games. The Cubs are starting Ben Brown in this game, who allowed three earned runs over 5.0 innings in his last outing against Oakland. The Padres are going with Hart, who allowed two earned runs over 5.0 innings against Cleveland. I do think this San Diego offense is due to wake up and I don’t love Brown on the mound for the Cubs, so I will take the Padres to win here. 

David Racey's Pick: Padres ML

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