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San Diego Padres vs Arizona Diamondbacks Prediction 08/04/2025 Today’s MLB Picks

Jul 10, 2025; San Diego, California, USA; San Diego Padres shortstop Xander Bogaerts (2) jumps for a high throw as Arizona Diamondbacks shortstop Blaze Alexander (9) steals second base during the eighth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

Jul 10, 2025; San Diego, California, USA; San Diego Padres shortstop Xander Bogaerts (2) jumps for a high throw as Arizona Diamondbacks shortstop Blaze Alexander (9) steals second base during the eighth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP San Diego Padres Arizona Diamondbacks
Team Records 62-51 54-59
Where Chase Field, Phoenix, Arizona
When Monday, August 4, 2025
Time 09:40 PM EDT
TV MLB Net

In this article, we will formulate a San Diego Padres vs Arizona Diamondbacks Prediction for this MLB game on Monday, August 4th at the Chase Field in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 53-59 record this season and are sitting on the 4th place of the NL West. The Diamondbacks have a 26-28 home record and are 53-51 in over/under They are coming off a 6-4 road victory over the A’s, and have back-to-back wins. Under is 9-1-2 in their last 12 games and are playing the Rangers and the Rockies next.

The Diamondbacks have a .249 batting average this season, .324 OBP and .435 slugging percentage. Arizona’s pitching staff has a 4.57 ERA and 1.34 WHIP. Geraldo Perdomo leads the Diamondbacks with 113 hits, while Josh Naylor is the team’s best hitter with a .292 batting average. Eugenio Suarez leads the team in RBI, with 87 and in home runs with 36.

Brandon Pfaadt (R) is the projected starting pitcher for the Diamondbacks, and he has a 10-7 record, 5.11 ERA and 1.31 WHIP.

San Diego Padres Preview

The San Diego Padres have a 62-50 record this season and are sitting on the second place of the NL West. They have a 26-31 road record, and are 46-63 in over/under. The Padres are coming off a 7-3 home victory over the Cardinals, and are 7-1 in their last 8 games. They are playing the Red Sox and the Giants next. 

The Padres have a .251 batting average this season, .319 OBP and .381 Slugging percentage. San Diego’s pitching staff has a 3.56 ERA and 1.21 WHIP.  Manny Machado leads the Padres with 129 hits and team-high .299 batting average. He also leads the team in RBI, with 72, adding a team-high 20 home runs. 

JP Sears (R) will take the mound for the Padres, making his first start with his new team. He has a 7-9 record, 4.95 ERA and 1.27 WHIP.

Why the Arizona Diamondbacks will win

Why the San Diego Padres will win

Total Runs Facts

Matchup/League Facts

San Diego Padres vs Arizona Diamondbacks Prediction

Both teams are tied 5-5 wins in their last 10 overall meetings, but the Diamondbacks are 4-3 in their seven meetings this season, having won their previous series in Arizona by 2-1 wins. Over is 4-2 in their last 6 meetings.

In this San Diego Padres vs Arizona Diamondbacks Prediction, the Padresare coming as -140 home favorites. The Padres are rightfully favored, as they have a better overall record, but both teams have exactly 26 home/away wins. Both pitchers have been in poor form lately, but Pfaadt has been good at home for the Dbacks, with a 2.68 home ERA. The Dbacks also have a better offense and I expect them to get to Sears, so I like the value of the home team as an underdog in this matchup. Take the Arizona Diamondbacks at home for plus money.

Nikos Lagouretos's Pick: Arizona Diamondbacks +120

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