Reds vs Guardians Prediction 6/10/25 MLB Picks

In this article, we will formulate a Reds vs Guardians prediction for this MLB game on Tuesday, June 10th at Progressive Field in Cleveland, Ohio. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 34-33 this year after they won game one in this series by a score of 7-4 on Monday night. Cincinnati trailed 3-2 in the third inning, but they scored the next four runs to pick up the win. The Reds recorded 16 hits and they committed one error in the game, while they were led by Fraley, who went 3-4 with one home run and two RBIs in the win. Cincinnati started Miley, who allowed five hits and three earned runs over 5.0 innings for the win, while Pagan got the save. 

Prior to this series, the Reds swept the Diamondbacks in three games and lost two out of three against the Brewers before that. Cincinnati has won four games in a row, and they are currently fourth in the NL Central standings. The Cincinnati pitching staff has a 3.71 ERA with a 1.19 WHIP and a .229 opponent batting average, while their offense has scored 308 runs with a .247 batting average and a .322 on-base percentage this season. Elly De La Cruz has led Cincinnati with 12 home runs and 43 RBIs, while Matt McLain has added seven home runs and 22 RBIs this year. The projected starting pitcher for Cincinnati is Andrew Abbott, who is 5-1 with a 2.18 ERA and a 1.06 WHIP over 53.2 innings pitched this year. 

Cleveland Guardians Betting Preview

The Cleveland Guardians are 34-31 this season after they lost game one on Monday night. Cleveland scored three runs in the third inning to erase a 2-0 deficit, but their pitching fell apart after that point for the loss. The Guardians recorded seven hits and they committed three errors in the game, while they were led by Naylor, Martinez, Santana, and Ramirez, who all had one RBI in the loss. Cleveland started Ortiz, who allowed nine hits and four earned runs over 4.2 innings for the loss, while Junis and Festa each allowed one earned run in relief. 

Prior to this series, the Guardians lost two out of three against the Astros and two out of three against the Yankees. Cleveland has lost four of their last five games, and they are currently third in the AL Central standings. The Cleveland pitching staff has a 3.98 ERA with a 1.38 WHIP and a .253 opponent batting average, while the offense has scored 254 runs with a .234 batting average and a .307 on-base percentage this season. Jose Ramirez has led Cleveland with 12 home runs and 32 RBIs, while Kyle Manzardo has added 11 home runs and 29 RBIs this year. The projected starting pitcher for Cleveland is Slade Cecconi, who is 1-2 with a 4.87 ERA and a 1.43 WHIP over 20.1 innings pitched this season. 

Why the Reds will beat the Guardians 

• The underdogs have won each of the Reds’ last five games.
• The Guardians have lost each of their last four games as favorites against NL Central opponents.
• The Reds have covered the run line in seven of their last eight games against American League opponents that held a winning record.
• The Guardians have failed to cover the run line in seven of their last eight home games against NL Central opponents that held a winning record.

Total Runs Facts

• Each of the Guardians’ last five home games against National League opponents have gone OVER the total runs line.
• Eight of the Reds’ last 10 night games after playing the previous day have gone UNDER the total runs line.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Guardians’ last seven home games.
• The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Reds’ last seven night games against AL Central opponents.

Cleveland Guardians Player Prop Facts

• Jose Ramirez has hit a home run in three of the Guardians’ last four games as home favorites against NL Central opponents.
• Carlos Santana has recorded at least one RBI in nine of his last 10 appearances with the Guardians as home favorites against the Reds.
• Jose Ramirez has scored at least one run in each of the Guardians’ last seven games against NL Central opponents at Progressive Field.
• Carlos Santana has recorded at least one hit in each of his last six home appearances against the Reds.
• Jose Ramirez has recorded a Single in each of the Guardians’ last six games at Progressive Field.

Cincinnati Reds Player Prop Facts

• Jake Fraley has hit a home run in three of his last four appearances with the Reds against AL opponents.
• Jake Fraley has recorded at least one RBI in each of his last four appearances against AL opponents.
• Will Benson has scored at least one run in each of his last five appearances against the Guardians after playing the previous day.
• TJ Friedl has recorded at least one hit in each of the Reds’ last 13 games as road underdogs against AL Central opponents.
• Jose Trevino has recorded at least one Single in each of his last 10 road appearances against AL Central opponents that held a winning record.
• Jeimer Candelario has recorded a Double in each of his last three appearances with his team as an underdog against AL Central opponents.

Reds vs Guardians Prediction 

Cincinnati was able to get the win in game one of this series on Monday night, and they have won four games in a row. The Reds are 16-17 on the road this year, while the Guardians are 18-14 at home. Cleveland has struggled in three straight series, and they are starting Cecconi, who has allowed seven earned runs in his last 9.1 innings. Cincinnati is going with Abbott, who has allowed one earned run or fewer in four of his last five starts, but did struggle last time out. The Reds are playing very well right now, and Abbott has been very reliable, so I like Cincinnati to win this one. 

David Racey's Pick: Reds ML