Reds vs Cardinals Prediction 6/6/2026 Today’s MLB Picks

In this article we will formulate a Reds vs Cardinals prediction for this MLB game on Saturday, June 6th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup. 

Cincinnati Reds Betting Preview

The Cincinnati Reds are 31-31 this season after they lost game one by a score of 3-10 last night. Cincinnati led 3-0 in the first inning, but they went scoreless over the last eight innings for the loss. The Reds recorded nine hits and they committed three errors in the game, while they were led by Stewart, who went 2-3 with two RBIs. Singer allowed four hits and one earned run over 4.0 innings for the loss, while Maxwell allowed four earned runs in relief. Prior to this series, Cincinnati lost two out of three against the Royals and two out of three against the Braves. 

This season, Cincinnati has a 4.81 ERA with a 1.47 WHIP and a .250 opponent batting average, while they have scored 267 runs with a .229 batting average and a .312 on base percentage. Elly De La Cruz has led the Reds with 12 home runs and 37 RBIs, while Sal Stewart has added 12 home runs and 39 RBIs. The projected starting pitcher for Cincinnati is Nick Lodolo, who is 2-1 with a 5.20 ERA and a 1.37 WHIP over 27.2 innings pitched this season. 

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 33-28 this year after they won game one by a score of 10-3 on Friday night. St. Louis trailed early in the game, but they scored the last 10 runs to pull away in the blowout win. The Cardinals recorded 10 hits in the game and they were led by Burleson, who went 2-4 with one home run and one RBI. Leahy allowed five hits and three earned runs over 4.0 innings, while Dobbins picked up the win in relief. Prior to this series, St. Louis lost two out of three against the Rangers, but did win two out of three against the Cubs before that. 

This season, St. Louis has a 4.13 ERA with a 1.36 WHIP and a .254 opponent batting average, while they have scored 267 runs with a .241 batting average and a .320 on base percentage. Jordan Walker has led the Cardinals with 15 home runs and 45 RBIs, while Alec Burleson has added eight home runs and 43 RBIs. The projected starting pitcher for St. Louis is Matthew Liberatore, who is 3-3 with a 4.35 ERA and a 1.50 WHIP over 62.0 innings pitched this year. 

Why the St. Louis Cardinals will win

• The Reds have lost each of their last eight road games against NL Central opponents that held a winning record.
• The favorites have won each of the Cardinals’ last six games at Busch Stadium.
• The Reds have failed to cover the run line in seven of their last eight day games against NL Central opponents.
• The favorites have covered the run line in five of the Cardinals’ last six games at Busch Stadium.
• The Cardinals have led after 5 innings in four of their last five games against National League opponents.
• The Cardinals have led after 3 innings in seven of their last eight Saturday day games as favorites.

Why the Cincinnati Reds will win

• The Cardinals have lost eight of their last nine home games against NL Central opponents following a win.
• The Reds have won four of their last six games as underdogs against the Cardinals following a road loss.
• The Cardinals have failed to cover the run line in 13 of their last 14 games as home favorites against National League opponents following a home win.
• The Reds have covered the run line in each of their last four road games against the Cardinals following a road loss.
• The Reds have led after 5 innings in six of their last eight day games.

Total Runs Facts

• Each of the Cardinals’ last five day games as favorites have gone UNDER the total runs line.
• Each of the Reds’ last four games as underdogs against NL Central opponents have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the last six games between the Reds and Cardinals at Busch Stadium.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Reds’ last six games against National League opponents.

Reds vs Cardinals Prediction

St. Louis was able to get the win on Friday to start this series and they have scored 5+ runs in three of their last five games. The Cardinals are 17-16 at home this year, while the Reds are 15-15 on the road. Cincinnati has lost three of their last four games and they have allowed 27 runs in those four contests. The Reds are starting Lodolo, who has allowed 3+ earned runs in four of his last five outings, while Liberatore has allowed 3+ earned runs in three of his last four starts. I don’t like either starter in this one, so I am backing the over here.

David Racey's Pick: Over 9.5