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Pittsburgh Pirates vs San Diego Padres Prediction 8/26/2026 Today’s MLB Picks

Aug 25, 2026; San Diego, California, USA;  San Diego Padres right fielder Jase Bowen (4) steals second base as Pittsburgh Pirates shortstop Jacob Gonzalez (26) loses the ball during the ninth inning at Petco Park.  Mandatory Credit: Denis Poroy-Imagn Images

Aug 25, 2026; San Diego, California, USA; San Diego Padres right fielder Jase Bowen (4) steals second base as Pittsburgh Pirates shortstop Jacob Gonzalez (26) loses the ball during the ninth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Pittsburgh Pirates San Diego Padres
Team Records 65-69 71-62
Spread +1.5 -186 -1.5 153
Moneyline +113 -136
Total Over 8 (-118) Under 8 (-102)
Where Petco Park, San Diego, California
When Wednesday, August 26, 2026
Time 04:10 PM EDT
TV MLB.TV
The Pittsburgh Pirates and San Diego Padres meet Wednesday in MLB action at Petco Park. Here’s a Pittsburgh Pirates vs San Diego Padres Prediction. This article will include a Pittsburgh Pirates vs San Diego Padres Pick.

Pittsburgh Pirates Betting Preview


The Pittsburgh Pirates are 65-69 this year and play the Giants and Cardinals next. The Pittsburgh Pirates are batting .253 on the season, with a .330 OBP and a .406 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.23 ERA and a 1.32 WHIP. Nick Gonzales leads the Pittsburgh Pirates with 145 hits and 56 RBI, while Bryan Reynolds and Brandon Lowe have combined for 253 hits and 146 RBI.

Bubba Chandler gets the ball for the Pittsburgh Pirates, and he is 6-8 with a 4.38 ERA and 114 strikeouts this season. This will be Chandler’s second career game against the San Diego Padres.

San Diego Padres Betting Preview


The San Diego Padres are 71-62 on the year and play the Reds and Rays next. The San Diego Padres are batting .237 on the season, have a .315 OBP, and have a .388 slugging percentage. The San Diego Padres’ pitching staff has a 3.97 ERA and a 1.29 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 146 hits and 67 RBI, while Jackson Merrill and Manny Machado have combined for 222 hits and 138 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 9-6 with a 4.19 ERA and 74 strikeouts this season. Vasquez is 0-0 with a 4.70 ERA and 9 strikeouts in his career against the Pittsburgh Pirates.

Why the San Diego Padres will win

Why the Pittsburgh Pirates will win

Total Runs Facts

San Diego Padres Player Prop Facts

Pittsburgh Pirates Player Prop Facts

Pittsburgh Pirates vs San Diego Padres Prediction


Chandler has been good this month and gives the Pirates a fighting chance most nights, but this is simply a matter of the Padres needing to win games to clinch a playoff spot. They can’t afford to lose games to low-level teams at home. Vasquez has also been solid in August, allowing 13 hits and 8 runs in 23 innings. The price is low, and the Padres are due for an offensive breakthrough after how last night played out. No excuses here. The Padres need to get their act together. I’ll lay this price with the Padres at home.

Randy Chambers's Pick: San Diego Padres

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