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Pittsburgh Pirates vs San Diego Padres Prediction 8/25/2026 Today’s MLB Picks

Aug 24, 2026; San Diego, California, USA;  Pittsburgh Pirates center fielder Jake Mangum (28) is tagged out by San Diego Padres second baseman Jake Cronenworth (9) after being caught in a run down during the tenth inning at Petco Park.  Mandatory Credit: Denis Poroy-Imagn Images

Aug 24, 2026; San Diego, California, USA; Pittsburgh Pirates center fielder Jake Mangum (28) is tagged out by San Diego Padres second baseman Jake Cronenworth (9) after being caught in a run down during the tenth inning at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Pittsburgh Pirates San Diego Padres
Team Records 64-69 71-61
Spread -1.5 171 +1.5 -210
Moneyline +103 -124
Total Over 7.5 (100) Under 7.5 (-120)
Where Petco Park, San Diego, California
When Tuesday, August 25, 2026
Time 09:40 PM EDT
TV ESPN Unlmtd
The Pittsburgh Pirates and San Diego Padres meet Tuesday in MLB action at Petco Park. Here’s a Pittsburgh Pirates vs San Diego Padres Prediction. This article will include a Pittsburgh Pirates vs San Diego Padres Pick.

Pittsburgh Pirates Betting Preview


The Pittsburgh Pirates are 64-69 this year and play the Giants and Cardinals next. The Pittsburgh Pirates are batting .254 on the season, with a .331 OBP and a .407 slugging percentage. The Pittsburgh Pirates’ pitching staff has a 4.29 ERA and a 1.32 WHIP. Nick Gonzales leads the Pittsburgh Pirates with 142 hits and 55 RBI, while Bryan Reynolds and Brandon Lowe have combined for 250 hits and 146 RBI.

Paul Skenes gets the ball for the Pittsburgh Pirates, and he is 9-11 with a 3.95 ERA and 171 strikeouts this season. This will be Skenes’ second career game against the San Diego Padres.

San Diego Padres Betting Preview


The San Diego Padres are 71-61 on the year and play the Reds and Rays next. The San Diego Padres are batting .239 on the season, have a .316 OBP, and have a .391 slugging percentage. The San Diego Padres’ pitching staff has a 4.01 ERA and a 1.29 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 146 hits and 67 RBI, while Jackson Merrill and Manny Machado have combined for 222 hits and 138 RBI.

Michael King gets the ball for the San Diego Padres, and he is 8-9 with a 3.38 ERA and 128 strikeouts this season. King is 2-0 with a 2.65 ERA and 21 strikeouts in his career against the Pittsburgh Pirates.

Why the San Diego Padres will win

Why the Pittsburgh Pirates will win

Total Runs Facts

San Diego Padres Player Prop Facts

Pittsburgh Pirates Player Prop Facts

Matchup/League Facts

Pittsburgh Pirates vs San Diego Padres Prediction


Skenes as an underdog is usually attractive, but he has allowed 48 hits and 29 earned runs in his last 46 innings. Skenes hasn’t been as dominant as he’s usually been. Skenes has a 4.40 ERA on the road through 61.1 innings. King has been more consistent as of late, and he has a solid 3.21 ERA and a .213 allowed batting average in 75.2 innings at home. The Padres are also closing in on a wild card spot while the Pirates’ season has been over for a while. I’ll take the low price on the Padres at home.

Randy Chambers's Pick: San Diego Padres

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