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Pittsburgh Pirates vs Chicago Cubs Prediction 4/10/2026 Today’s MLB Picks

Mar 29, 2026; Chicago, Illinois, USA;  Chicago Cubs pitcher Shota Imanaga (18) delivers during the first inning against the Washington Nationals at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

Mar 29, 2026; Chicago, Illinois, USA; Chicago Cubs pitcher Shota Imanaga (18) delivers during the first inning against the Washington Nationals at Wrigley Field. Mandatory Credit: Matt Marton-Imagn Images

MATCHUP Pittsburgh Pirates Chicago Cubs
Team Records 7-5 6-6
Spread +1.5 -175 -1.5 144
Moneyline +119 -143
Total Over 7 (102) Under 7 (-123)
Where Wrigley Field, Chicago, Illinois
When Friday, April 10, 2026
Time 02:20 PM EDT
TV MLB.TV

In this article, we will formulate a Pirates vs Cubs Prediction for this MLB matchup on Friday, April 10th in the opening game of this series. Let’s take a look at the prediction for this MLB matchup.

Chicago Cubs Preview

The Chicago Cubs have a 6-6 record this season and are sitting in the fifth place of the NL Central. They have a 3-3 home record and are coming off a 6-2 road win against the Rays. Their previous three games were a 9-2 road win against the Rays, a 4-6 and a 5-6 road loss against the Guardians.

The Cubs have a .223 batting average this season, .312 OBP and .368 Slugging percentage. Chicago’s pitching staff has a 3.43 ERA and 1.12 WHIP. Nico Hoerner is the team’s best hitter with a .333 batting average, also leading the team in RBI with 9. Ian Happ adds a team-high 4 home runs.

Shota Imanaga (L) is the projected starting pitcher for the Cubs, and he has a 0-1 record, 4.50 ERA and 1.20 WHIP.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 7-5 record this season and are sitting in the fourth place of the NL Central. They have a 3-3 away record and are coming off a 2-8 home loss against the Padres. Their previous three games were a 7-1 home win against the Padres, a 0-5 home loss, and an 8-2 home win against the Orioles.

The Pirates have a .244 batting average this season, .335 OBP and .380 Slugging percentage. Pittsburgh’s pitching staff has a 3.33 ERA and 1.30 WHIP. Ryan O’Hearn is the team’s best hitter with a .350 batting average. Oneil Cruz leads the team in RBI with 12, also adding a team-high 4 home runs.

Carmen Mlodzinski (R) is the projected starting pitcher for the Pirates, and he has a 0-0 record, 4.00 ERA and 1.56 WHIP.

Pittsburgh Pirates @ the Chicago Cubs Betting Trends: April 10, 2026

Why the Chicago Cubs will win

Why the Pittsburgh Pirates will win

Total Runs Facts

Chicago Cubs Player Prop Facts

Pittsburgh Pirates Player Prop Facts

Matchup/League Facts

Pirates vs Cubs Prediction

The Cubs are 8-1 in their last 9 meetings against the Pirates and are 5-1 in their last 6 meetings in Chicago.

In this Pirates vs Cubs Prediction, the Cubs are coming as -147 home favorites. The Cubs are coming off back-to-back wins and put Imanaga on the mound who bounced back after a terrible first start to the season and he was almost unhittable in his two starts against the Pirates last season. On the flip side, Mlodzinski has been decent this season but I cannot trust him on the road in this spot and the Pirates have a slightly weaker offense. Take the Cubs on the moneyline to get the job done at home in this one.

Nikos Lagouretos's Pick: Chicago Cubs ML

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