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Pittsburgh Pirates vs Arizona Diamondbacks Prediction 5/28/25 MLB Picks

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Arizona Diamondbacks (27-28) vs Pittsburgh Pirates (20-36)

Game Info: Wednesday, May 28, 2025 at 3:40 pm (Chase Field)

The Line: Betting Odds: Arizona Diamondbacks -130 / Pittsburgh Pirates +110 — Over/Under: 7.5

(Get latest betting odds)

The Pittsburgh Pirates are visiting the Arizona Diamondbacks on Wednesday, May 28th at the Chase Field in the third game of this series, with both teams being tied 1-1 wins. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Pittsburgh Pirates vs Arizona Diamondbacks Prediction. We will examine:

The Arizona Diamondbacks’ recent form and player performance

The Pittsburgh Pirates’ recent form and player performance

Recent betting trends and streaks involving the Arizona Diamondbacks

Recent betting trends and streaks involving the Pittsburgh Pirates

Recent betting trends in games played between the Pittsburgh Pirates vs Arizona Diamondbacks

A summary that ties it all together and produces a favorable betting outcome for the Pittsburgh Pirates vs Arizona Diamondbacks game

Arizona Diamondbacks Preview

The Arizona Diamondbacks have a 27-28 record this season and are sitting in 4th place in the NL West. The Diamondbacks have a 14-14 home record and are 23-27 in over/under. They are coming off a 6-9 home defeat by the Pirates, and are 1-6 in their last 7 games. Under is 4-2-1 in their last 7 games, and they are playing the Braves and the Nationals next.

The Diamondbacks have a .256 batting average this season, a .333 OBP, and a .448 slugging percentage. Arizona’s pitching staff has a 4.65 ERA and 1.32 WHIP. Josh Naylor leads the Diamondbacks with 58 hits, while Geraldo Perdomo is the team’s best hitter with a .296 batting average. Eugenio Suarez leads the team in RBI, with 41, and Corbin Carroll adds a team-high 15 home runs.

Zac Gallen (R) will take the mound for the Diamondbacks, and he has a 3-6 record, 5.25 ERA, and 1.36 WHIP. He has been weaker at home, with a 6.03 ERA across seven home starts, and he has given up 4+ runs in each of his last three starts. Zac Gallen is 3-2 with an ERA of 3.34 and 25 strikeouts in 5 appearances versus the Pirates in his career.

Pittsburgh Pirates Preview

The Pittsburgh Pirates have a 20-36 record this season and are sitting in last place in the NL Central. They have a 7-20 road record, and are 21-32 in over/under. They are coming off a 9-6 road victory over the Dbacks, which ended their previous two-game losing streak. Over is 4-2 in their last 6 games are playing the Padres and the Astros next.

The Pirates have a .225 batting average this season, a .305 OBP, and a .334 slugging percentage. Pittsburgh’s pitching staff has a 4.05 ERA and 1.27 WHIP. Bryan Reynolds leads the Pirates with 47 hits, adding a team-high 30 RBI. Andrew McCutchen is the team’s best hitter with a .261 batting average.

Paul Skenes (R) will take the mound for the Pirates, and he has a 3-5 record, 2.36 ERA, and 0.95 WHIP. He has been better on the road, with a 1.40 ERA across six road starts, and he has been on fire lately, with one earned run in each of his last three starts, across 20 innings pitched. In his only previous start against the D-backs last season, he gave up 2 runs in 5.1 innings of work.  

Why the Arizona Diamondbacks will win

Why the Pittsburgh Pirates will win

Total Runs Facts

Matchup/League Facts

Pittsburgh Pirates vs Arizona Diamondbacks Prediction

The Diamondbacks are 8-4 in their last 12 meetings against the Pirates, and 5-3 in their last 8 meetings in Arizona. Over is 5-2 in their last 7 meetings.

In this Pittsburgh Pirates vs Arizona Diamondbacks Prediction, the Diamondbacks are coming as -130 home favorites. The Dbacks are rightfully favored, as they have a better record this season, and the Pirates have been horrendous on the road. The Dbacks have been mediocre at home and have a weaker bullpen, and they put Zac Gallen on the mound, who has been struggling mightily this season. On the other hand, Skenes looks sharp this season and has been in excellent form. I expect Skenes to keep the Dbacks’ bats at bay, so I like the Pittsburgh Pirates on the moneyline in the first 5 innings of this game.

Nikos Lagouretos's Pick: Pittsburgh Pirates F5 ML

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