Pittsburgh (58-75) vs St. Louis (65-68)
August 27, 2025 at 07:45 PM EDT
The Line: Betting Odds: St. Louis — Over/Under:
In this article we will formulate a Pirates vs Cardinals prediction for this MLB game on Wednesday, August 27th at Busch Stadium in St. Louis, Missouri. Let’s take a look at the prediction for this MLB matchup.
Pittsburgh Pirates Betting Preview
The Pittsburgh Pirates are 58-75 this year after they split the first two games in this series by scores of 6-7 and 8-3. In their game two win, Pittsburgh scored five runs in the first inning, which allowed them to coast to the easy victory. The Pirates recorded 11 hits in the game and they were led by McCutchen and Davis, who both had two RBIs in the win. Pittsburgh started Keller, who allowed three hits and three earned runs over 6.0 innings for the win, while Nicolas and Mattson finished the game.
Prior to this series, the Pirates swept the Rockies in three games and won two out of three against the Blue Jays. Pittsburgh has won five of their last six games and they are currently last in the NL Central standings. The Pittsburgh pitching staff has a 3.95 ERA with a 1.22 WHIP and a .237 opponent batting average, while their offense has scored 481 runs with a .235 batting average and a .306 on base percentage this season. Oneil Cruz has led Pittsburgh with 18 home runs and 52 RBIs, while Bryan Reynolds has added 14 home runs and 66 RBIs this year. The projected starting pitcher for Pittsburgh is TBD.
St. Louis Cardinals Betting Preview
The St. Louis Cardinals are 65-68 this season after they lost game two in this series by a score of 8-3. St. Louis fell behind 8-0 in the third inning and never got back into the blowout loss. The Cardinals recorded three hits and they committed one error in the game, while they were led by Gorman, who went 1-4 with one home run and two RBIs in the loss. St. Louis started Pallante, who allowed eight hits and seven earned runs over 5.0 innings for the loss, while Graceoff pitched two scoreless innings in relief.
Prior to this series, the Cardinals lost two out of three against the Rays, but did win two out of three against the Marlins before that. St. Louis has lost three of their last four games and they are fourth in the NL Central standings. The St. Louis pitching staff has a 4.33 ERA with a 1.31 WHIP and a .258 opponent batting average, while their offense has scored 583 runs with a .248 batting average and a .317 on base percentage this season. Wilson Contreras has led St. Louis with 19 home runs, 73 RBIs, and four stolen bases, while Alec Burleson has added 16 home runs and 60 RBIs this year. The projected starting pitcher for St. Louis is Sonny Gray, who is 12-6 with a 4.33 ERA and a 1.20 WHIP over 145.1 innings pitched this season.
Why the Cardinals will beat the Pirates
- The Cardinals have won 10 of their last 11 games against the Pirates at Busch Stadium following a loss.
- The Pirates have lost nine of their last 10 road games against NL Central opponents following a win.
- The Pirates have failed to cover the run line in each of their last six Wednesday road games against NL Central opponents.
- The Cardinals have covered the run line in 12 of their last 15 night games against National League opponents following a loss.
Why the Pirates will beat the Cardinals
- The Cardinals have lost each of their last six Wednesday games at Busch Stadium.
- The Pirates have won four of their last five games against the Cardinals.
- The Cardinals have failed to cover the run line each of their last seven games at Busch Stadium against teams that held a losing record.
- The Pirates have covered the run line in each of their last six games against National League opponents.
- The Cardinals have trailed after 3 innings in four of their last five night games against National League opponents.
- The Cardinals have lost the first inning in each of their last four night games at Busch Stadium.
- The Cardinals have trailed after 5 innings in eight of their last nine Wednesday games.
Total Runs Facts
- Seven of the Cardinals’ last eight night games after playing the previous day have gone OVER the total runs line.
- Each of the Pirates’ last three night games against NL Central opponents have gone OVER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Cardinals’ last four night games.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in five of the Pirates’ last six night games against National League opponents.
St. Louis Cardinals Player Prop Facts
- Sonny Gray has recorded a win in six of his last eight home appearances against the Pirates.
- Willson Contreras has hit a home run in three of the Cardinals’ last five night games.
- Sonny Gray has recorded seven or more strikeouts in seven of his last eight home appearances against the Pirates.
- Brendan Donovan has recorded at least one hit in each of his 21 previous appearances against the Pirates at Busch Stadium.
Pittsburgh Pirates Player Prop Facts
- Bryan Reynolds has hit a home run in three of the Pirates’ last 10 games against the Cardinals.
- Bryan Reynolds has recorded at least one Double in each of the Pirates’ last five night games against NL opponents that held a losing record.
- Tommy Pham has recorded at least one hit in each of his last 10 Wednesday appearances.
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Pirates vs Cardinals Prediction
Pittsburgh was able to jump on the Cardinals in the first inning of game one to even the series at one, but they have struggled to string wins together away from home. The Pirates are 19-45 on the road this year, while the Cardinals are 36-31 at home. St. Louis has allowed 6+ runs in four straight games and they are starting Gray, who has allowed nine earned runs and 15 hits in his last 10.0 innings. Pittsburgh hasn’t named a starter for this contest, but I think we will see plenty of scoring. Take the over in this one.