| MATCHUP | Philadelphia Phillies | San Diego Padres |
|---|---|---|
| Team Records | 28-27 | 31-23 |
| Spread | -1.5 118 | +1.5 -142 |
| Moneyline | -150 | +125 |
| Total | Over 7 (-119) | Under 7 (-102) |
| Where | Petco Park, San Diego, California | |
| When | Wednesday, May 27, 2026 | |
| Time | 04:10 PM EDT | |
| TV | MLB.TV | |
The Philadelphia Phillies and the San Diego Padres meet Wednesday in MLB action from Petco Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Philadelphia Phillies vs. San Diego Padres prediction.
Starting Pitching Matchup
The Philadelphia Phillies will send out Cristopher Sanchez for the start here and Sanchez is 5-2 with a 1.62 ERA and 86 strikeouts this season. In his career, Sanchez is 3-1 with a 2.05 ERA and 21 strikeouts against the Padres. Walker Buehler will start for the Padres here and is 3-2 with a 5.05 ERA and 41 strikeouts this season. In his career, Buehler is 0-1 with a 5.16 ERA and 19 strikeouts against the Phillies.
Philadelphia Phillies Recap
The Philadelphia Phillies come into this game looking to add on to their 4-3 win over the Padres from Tuesday’s matchup to sit at 28-27 this season. After this series, the Phillies will head on the road for a series against the Los Angeles Dodgers.
Phillies Pick Up Back-To-Back Wins
Entering Tuesday, Adolis Garcia has 37 hits with 7 doubles, 4 home runs and 15 RBIs while Kyle Schwarber has 45 hits with 9 doubles, 21 home runs and 37 RBIs. Brandon Marsh has 57 hits with 9 doubles, 5 home runs and 24 RBIs while Justin Crawford also has 36 hits with 7 doubles, 2 triples, 2 home runs and 12 RBIs. Trea Turner has 48 hits with 9 doubles, 5 home runs and 16 RBIs and Bryce Harper’s added 52 hits with 10 doubles, 12 home runs and 32 RBIs this season.
San Diego Padres Recap
The San Diego Padres come into this game looking to bounce back from their loss at the hands of the Phillies on Tuesday to sit at 31-23 this season. After this series, the Padres will head on the road for a series against the Washington Nationals.
Padres Lose 3 In A Row
Going into Tuesday, Jackson Merrill has 37 hits with 10 doubles, 4 home runs and 19 RBIs while Ramon Laureano has 35 hits with 5 doubles, 2 triples, 6 home runs and 20 RBIs as well on the year. Fernando Tatis Jr. has 49 hits with 6 doubles and 16 RBIs and Xander Bogaerts has 45 hits with 3 doubles, 7 home runs and 24 RBIs. Manny Machado also has 31 hits with 5 doubles, 8 home runs and 25 RBIs as well on the year.
Philadelphia Phillies @ San Diego Padres Betting Trends: May 27, 2026
- Probable Starting Pitcher: Walker Buehler Record this season: 3-2 ERA: 5.05
- Home Record: 1-1
- Last 5 against Phillies: 1-1
Why the San Diego Padres will win
- The underdogs have won three of the Padres’ last four games.
- The Phillies have lost three of their last four games as favorites against NL West opponents following a road win.
- The Phillies have failed to cover the run line in each of their last four games as favorites against NL West opponents following a road win.
- The Padres have covered the run line in 18 of their last 21 day games against National League opponents following a loss.
- The Padres have led after 5 innings in six of their last eight games as underdogs.
- The Padres have led after 3 innings in six of their last eight home games against NL East opponents that held a winning record.
- Probable Starting Pitcher: Cristopher Sanchez Record this season: 5-2 ERA: 1.62
- Road Record: 1-1
- Last 5 against Padres: 3-1
Why the Philadelphia Phillies will win
- The Phillies have won each of their last seven road games against National League opponents.
- The Padres have lost each of their last five home games against the Phillies following a loss.
- The Phillies have covered the run line in each of their last seven road games against National League opponents.
- The Padres have failed to cover the run line in each of their last five home games against the Phillies following a loss.
- The Phillies have led after 5 innings in each of their last six day games against the Padres at Petco Park.
- The Phillies have won the first inning in each of their last four games as road favorites.
- The Phillies have led after 3 innings in each of their last four games as road favorites.
Total Runs Facts
- Each of the Phillies’ last seven day games against NL West opponents have gone UNDER the total runs line.
- Twelve of the Padres’ last 13 home games after playing the previous day have gone UNDER the total runs line.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last six games against National League opponents.
- The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Phillies’ last five games as road favorites.
San Diego Padres Player Prop Facts
- Miguel Andujar has hit a home run in two of his last three appearances with his team as an underdog against the Phillies.
- Nick Castellanos has recorded at least one hit in each of his last 10 home appearances against NL East opponents that held a winning record.
- Fernando Tatis Jr. ranks T8th in the league in Steals (13) this season.
Philadelphia Phillies Player Prop Facts
- Kyle Schwarber has hit at least one home run in each of the Phillies’ last six games as favorites against NL West opponents.
- J.T. Realmuto has recorded at least one hit in each of his last nine appearances with the Phillies as favorites against the Padres.
- Kyle Schwarber ranks 1st in the league in Home Runs (21) this season.
Matchup/League Facts
- The Padres rank 30th in the league for hits this season (382).
- The Padres rank 30th in the league for batting average this season (.218).
- The Phillies rank 2nd in the league for strikeouts this season (519).
- The Phillies rank 2nd in the league for walks allowed this season (152).
Philadelphia Phillies vs. San Diego Padres Prediction
I’m backing the Phillies here. If you’re San Diego and couldn’t do enough to get the win off of Aaron Nola, you’re definitely not getting past Cristopher Sanchez who has been lights out in May and has been flat out dominant over his last five starts while the Padres have struggled against lefties. Walker Buehler’s not the answer for this Padres rotation and I think the Phillies get it done again here. Give me Philadelphia.