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Philadelphia Phillies vs San Diego Padres Prediction 5/26/2026 Today’s MLB Picks

May 25, 2026; San Diego, California, USA; Philadelphia Phillies first baseman Bryce Harper (3) grabs his helmet after hitting a long fly ball during the ninth inning against the San Diego Padres at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

May 25, 2026; San Diego, California, USA; Philadelphia Phillies first baseman Bryce Harper (3) grabs his helmet after hitting a long fly ball during the ninth inning against the San Diego Padres at Petco Park. Mandatory Credit: Denis Poroy-Imagn Images

MATCHUP Philadelphia Phillies San Diego Padres
Team Records 27-27 31-22
Spread -1.5 165 +1.5 -202
Moneyline +102 -122
Total Over 8 (-102) Under 8 (-118)
Where Petco Park, San Diego, California
When Tuesday, May 26, 2026
Time 09:40 PM EDT
TV MLB.TV
The Philadelphia Phillies and San Diego Padres meet Tuesday in MLB action at Comerica Park. Here’s a Philadelphia Phillies vs San Diego Padres Prediction. This article will include a Philadelphia Phillies vs San Diego Padres Pick.

Philadelphia Phillies Betting Preview


The Philadelphia Phillies are 27-27 on the year and play the Dodgers and Padres next. The Philadelphia Phillies are batting .227 on the season, with a .296 OBP and a .384 slugging percentage. The Philadelphia Phillies pitching staff has a 4.06 ERA and a 1.32 WHIP. Brandon Marsh leads the Philadelphia Phillies with 57 hits and 24 RBI, while Trea Turner and Bryce Harper have combined for 100 hits and 48 RBI.

Aaron Nola gets the ball for the Philadelphia Phillies, and he is 2-4 with a 6.04 ERA and 51 strikeouts this season. Nola is 3-4 with a 3.26 ERA and 77 strikeouts in his career against the San Diego Padres.

San Diego Padres Betting Preview


The San Diego Padres are 31-22 on the year and play the Nationals and Phillies next. The San Diego Padres are batting. 219 on the season, have a .294 OBP, and have a .363 slugging percentage. The San Diego Padres’ pitching staff has a 3.84 ERA and a 1.25 WHIP. Fernando Tatis Jr. leads the San Diego Padres with 49 hits and 16 RBI, while Miguel Andujar and Xander Bogaerts have combined for 88 hits and 41 RBI.

Randy Vasquez gets the ball for the San Diego Padres, and he is 5-2 with a 2.96 ERA and 45 strikeouts this season. This will be Vasquez’s second career game against the Philadelphia Phillies.

Why the San Diego Padres will win

Why the Philadelphia Phillies will win

Total Runs Facts

San Diego Padres Player Prop Facts

Philadelphia Phillies Player Prop Facts

Matchup/League Facts

Philadelphia Phillies vs San Diego Padres Prediction


The Phillies have cooled off over the last week, and it feels like the Padres are due for a bounce-back effort. We know what Nola is capable of when he’s right, but he has a 6.04 ERA and 1.56 WHIP through 50.2 innings. Nola has a 6.10 ERA and a .283 allowed batting average in 31 road innings. Vasquez looks like an all-star with a 2.96 ERA and 1.19 WHIP. We’re getting a near pick ’em price. Give me the Padres at home with the pitcher in far better form.

Randy Chambers's Pick: San Diego Padres

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