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Philadelphia Phillies vs Pittsburgh Pirates Prediction 5/16/2026 Today’s MLB Picks

Apr 30, 2026; Philadelphia, Pennsylvania, USA; Philadelphia Phillies pitcher Cristopher Sanchez (61) throws a pitch against the San Francisco Giants at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

Apr 30, 2026; Philadelphia, Pennsylvania, USA; Philadelphia Phillies pitcher Cristopher Sanchez (61) throws a pitch against the San Francisco Giants at Citizens Bank Park. Mandatory Credit: Bill Streicher-Imagn Images

MATCHUP Philadelphia Phillies Pittsburgh Pirates
Team Records 22-23 24-21
Spread -1.5 -102 +1.5 -118
Moneyline -170 +140
Total Over 8 (-115) Under 8 (-104)
Where PNC Park, Pittsburgh, Pennsylvania
When Saturday, May 16, 2026
Time 04:05 PM EDT
TV MLB.TV
In this article, we will formulate a Phillies vs Pirates Prediction for this MLB matchup on Saturday, May 16th in the second game of this series. Let’s take a look at the prediction for this MLB matchup.

Pittsburgh Pirates Preview


The Pittsburgh Pirates have a 24-21 record this season and are sitting in the fourth place of the NL Central. They have a 13-11 home record and are coming off a 9-11 loss at home against the Phillies. They will face the Cardinals and the Blue Jays next.

The Pirates have a .251 batting average this season, .337 OBP and .395 Slugging percentage. Pittsburgh’s pitching staff has a 3.81 ERA and 1.22 WHIP. Nick Gonzales is the team’s best hitter with a .313 batting average. Oneil Cruz leads the team in RBI with 32, and Brandon Lowe adds a team‑high 12 home runs.

Bubba Chandler (R) is the projected starting pitcher for the Pirates, and he has a 1-4 record, 4.62 ERA and 1.46 WHIP.

Philadelphia Phillies Preview


The Philadelphia Phillies have a 22-23 record this season and are sitting in the second place of the NL East. They have a 10-11 away record and are coming off an 11-9 win on the road against the Pirates. They will face the Reds and the Guardians next.

The Phillies have a .235 batting average this season, .301 OBP and .391 Slugging percentage. Philadelphia’s pitching staff has a 4.41 ERA and 1.39 WHIP. Brandon Marsh is the team’s best hitter with a .336 batting average. Kyle Schwarber leads the team in RBI with 35, also adding a team‑high 20 home runs.

Cristopher Sanchez (L) is the projected starting pitcher for the Phillies, and he has a 4-2 record, 2.11 ERA and 1.28 WHIP.

Philadelphia Phillies @ Pittsburgh Pirates Betting Trends: May 16, 2026


Why the Pittsburgh Pirates will win


Why the Philadelphia Phillies will win

Total Runs Facts

Pittsburgh Pirates Player Prop Facts

Philadelphia Phillies Player Prop Facts

Matchup/League Facts

Phillies vs Pirates Prediction


The Pirates are 3-1 in their last 4 meetings against the Phillies and are 6-2 in their last 8 meetings in Pittsburgh.

In this Phillies vs Pirates Prediction, the Phillies are coming as -170 road favorites. The Phillies have the pitching advantage today as Cristopher Sanchez goes up against Bubba Chandler. Sanchez has back-to-back shutouts while Chandler has given up 13 runs across his last four starts and the Pirates are weaker against lefties. The Phillies also have a better bullpen so I expect them to get the job done on the road in this one.

Nikos Lagouretos's Pick: Philadelphia Phillies ML

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