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Philadelphia Phillies vs Houston Astros Prediction 06/26/2025 Picks

Jun 20, 2025; Anaheim, California, USA; Houston Astros starting pitcher Hunter Brown (58) throws in the second inning against the Los Angeles Angels at Angel Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Jun 20, 2025; Anaheim, California, USA; Houston Astros starting pitcher Hunter Brown (58) throws in the second inning against the Los Angeles Angels at Angel Stadium. Mandatory Credit: Kirby Lee-Imagn Images

Philadelphia (47-33) vs Houston (47-33)

June 26, 2025 at 02:10 PM EDT

The Line: Betting Odds: Houston -1.5 — Over/Under: +7

(Get latest betting odds)

In this article, we will formulate a Phillies vs Astros prediction for this MLB game on Thursday, June 26, at Daikin Park in Houston, Texas. Let’s take a look at the prediction for this MLB matchup.

Philadelphia Phillies Betting Preview

The Philadelphia Phillies (47-33, 21-19 Away) won four straight series after beating the Chicago Cubs, sweeping the Toronto Blue Jays, and defeating the Miami Marlins and New York Mets. However, they are not going to win the current one against the Houston Astros after losing the first two without scoring a single run in the process. In last night’s 2-0 defeat, Zack Wheeler took the loss after allowing one run on four hits with eight strikeouts and three walks in 6.0 innings.

This year, the Phillies average 4.61 runs per game (10th in the MLB) on a .256/.330/.402 triple-slash. When it comes to pitching, the Phillies’ staff has a 3.84 ERA (12th) and 1.27 WHIP (16th). Kyle Schwarber leads the Phillies with a .250 batting average, 24 home runs, and 55 RBI this season.

The projected starting pitcher for the Phillies is Christopher Sanchez, who is 6-2 in 15 starts this season, with a 2.87 ERA and 1.19 WHIP in 87.2 innings.

Houston Astros Betting Preview

The Houston Astros (47-33, 31-13 Home) extended their unbeaten streak to ten series following two wins against the Phillies. During this positive stretch, the Astros beat the Seattle Mariners, Minnesota Twins (sweep), and most recently, the Los Angeles Angels. Houston opened the series against Philly with a 1-0 win and then kept the visitors off the scoreboard again in a 2-0 victory on Wednesday. Colton Gordon had the games of his career after allowing no runs on four hits with four strikeouts and no walks across 5.0 innings of work.

This season, the Astros average 4.20 runs per game (20th in the MLB) on a .256/.322/.400 triple-slash. When it comes to pitching, the Astros’ staff has a 3.43 ERA (5th) and 1.15 WHIP (2nd). Isaac Paredes leads the Astros with a .254 batting average, 16 home runs, and 46 RBI this season.

Hunter Brown will take the mound for the Astros on Thursday. The 26-year-old right-hander has an 8-3 record in 15 starts this year with a 1.88 ERA and 0.92 WHIP in 91.0 innings.

Total Runs Facts

Eleven of the last 12 games between the Phillies and Astros have gone UNDER the total runs line.
Seven of the Phillies’ last eight games as road underdogs have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the Phillies’ last eight road games against AL West opponents.
The ‘Inning 1 UNDER 0.5 runs’ market has hit in each of the Astros’ last four games as favorites against NL East opponents.

Matchup/League Facts

The Astros rank 1st in the league for hits allowed this season (573).
The Astros rank 2nd in the league for runs allowed this season (287).
The Phillies are one of only three teams in the league to rank top 10 in both strikeouts and walks allowed this season.
The Phillies rank 4th in the league for on-base percentage this season (.330).

Phillies vs Astros Prediction

The Astros won six of the previous ten H2H encounters, including the last three in which the Phillies failed to score a single run. This matchup has Under written all over it, as nine of the last ten H2Hs went Under, and I am going with another low-scoring affair in this one. Christopher Sanchez allowed eight runs in his previous five starts and has four consecutive quality starts. Hunter Brown, on the other hand, surrendered five runs in his last five starts and allowed more than two runs in a game only twice this season. Although I expect the Phillies to finally score against Houston, don’t expect a high-scoring tilt. It will be all about the pitching and defense.

Oliver Zivic's Pick: Under 7.5

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