Padres vs White Sox Prediction 9/21/2025 Today’s MLB Picks

In this article we will formulate a Padres vs White Sox prediction for this MLB game on Sunday, September 21st at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

San Diego Padres Betting Preview

The San Diego Padres are 84-71 this year after they split the first two games in this series by scores of 3-4 and 7-3. In their game two win, San Diego trailed 2-1 in the third inning, but scored the next six runs to pull away with the victory. The Padres recorded 11 hits in the game and they were led by O’Hearn, who went 3-4 with three RBIs in the win. SD started Darvish, who allowed six hits and two earned runs over 4.2 innings, while Morejon picked up the win in relief. 

Prior to this series, the Padres lost two out of three against the Mets, but did win three out of four against the Rockies before that. San Diego has lost three of their last five games and they are second in the NL West standings. The San Diego pitching staff has a 3.69 ERA with a 1.20 WHIP and a .226 opponent batting average, while their offense has scored 662 runs with a .252 batting average and a .321 on base percentage this season. Manny Machado has led San Diego with 26 home runs and 93 RBIs, while Fernando Tatis has added 22 home runs and 65 RBIs this year. The projected starting pitcher for San Diego is Michael King, who is 4-3 with a 3.84 ERA and a 1.17 WHIP over 65.2 innings pitched this year. 

Chicago White Sox Betting Preview

The Chicago White Sox are 58-97 this season after they lost game two by a score of 7-3 on Saturday night. Chicago led 1-0 and 2-1, but didn’t score again until the ninth, which was way too late. The White Sox recorded eight hits in the game and they were led by Sosa, Vargas, and Teel, who all had one RBI in the loss. Chicago started Gomez, who allowed six hits and three earned runs over 5.1 innings for the loss, while Ellard allowed two earned runs in relief. 

Prior to this series, the White Sox lost all three against the Orioles and all three against the Guardians. Chicago has lost seven of their last eight games and they are still last in the Central. The Chicago pitching staff has a 4.24 ERA with a 1.36 WHIP and a .247 opponent batting average, while the offense has scored 616 runs with a .233 batting average and a .302 on base percentage this season. Lenyn Sosa has led Chicago with 21 home runs and 71 RBIs, while Andrew Benintendi has added 20 home runs and 62 RBIs this year. The projected starting pitcher for Chicago is Sean Burke, who is 4-10 with a 4.29 ERA and a 1.47 WHIP over 126.0 innings pitched this season. 

Why the Padres will beat the White Sox 

The White Sox have lost seven of their last eight games.
The Padres have won each of their last six games against the White Sox following a win.
The White Sox have failed to cover the run line in each of their last four home games after playing the previous day.
The road team has covered the run line in five of the White Sox’s last six games.

Total Runs Facts

Eight of the Padres’ last 10 road games against American League opponents have gone OVER the total runs line.
Four of the last five games between the Padres and White Sox at Rate Field have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the White Sox’s last nine games at Rate Field.
The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Padres’ last six road games.

Chicago White Sox Player Prop Facts

Miguel Vargas has hit a home run in two of the White Sox’s last three games against the Padres.
Luis Robert has recorded at least one hit in each of his last six appearances against NL opponents.

San Diego Padres Player Prop Facts

Jackson Merrill has hit a home run in three of the Padres’ last four games against opponents that held a losing record.
Fernando Tatis Jr. has recorded at least one hit in each of the Padres’ last eight games as road favorites.
Jackson Merrill has recorded a Double in each of his last three appearances against AL Central opponents.

Padres vs White Sox Prediction 

San Diego was able to finally wake up in the middle innings of game two to get the win, but they are now four games back in the race for the NL West. The Padres are 37-43 on the road this year, while the White Sox are 33-47 at home. Chicago has lost seven of their last eight games and they are starting Burke, who has allowed two earned runs or fewer in three of his last four outings, but doesn’t pitch very deep into games. The Padres are going with King, who has allowed 8, 2, 2, and 3 earned runs in his last four outings. I think we could see a higher scoring game here, but I will back the Padres on the run line once again.