Orioles vs White Sox Prediction 9/16/2025 Today’s MLB Picks

In this article we will formulate an Orioles vs White Sox prediction for this MLB game on Tuesday, September 16th at Rate Field in Chicago, Illinois. Let’s take a look at the prediction for this MLB matchup. 

Baltimore Orioles Betting Preview

The Baltimore Orioles are 70-80 this season after they won game one by a score of 4-1 on Monday night. Baltimore trailed 1-0 in the first inning, but they scored once in the third and three times in the sixth to get the victory. The Orioles recorded seven hits in the game and they were led by Cowser, who went 1-4 with one home run and three RBIs in the win. Baltimore started Bradish, who allowed four hits and one earned run over 5.0 innings for the win, while Enns picked up the save. 

Prior to this series, the Orioles lost all three against the Blue Jays, but did win all three against the Pirates before that. Baltimore has lost three of their last four games and they are last in the AL East standings. The Baltimore pitching staff has a 4.61 ERA with a 1.37 WHIP and a .260 opponent batting average, while their offense has scored 639 runs with a .239 batting average and a .307 on base percentage this season. Jackson Holliday has led Baltimore with 17 home runs and 55 RBIs, while Gunnar Henderson has added 16 home runs and 62 RBIs this year. The projected starting pitcher for Baltimore is Dean Kremer, who is 9-10 with a 4.43 ERA and a 1.26 WHIP over 158.1 innings pitched this season. 

Chicago White Sox Betting Preview

The Chicago White Sox are 57-94 this year after they lost game one by a score of 4-1 on Monday night. Chicago took a 1-0 lead in the first inning, but went scoreless over the last eight innings for the loss. The White Sox recorded four hits in the game and they were led by Mead, who went 1-4 with one RBI in the loss. Chicago started Gilbert, who opened the game, while Burke was the bulk pitcher, but Wilson ended up getting the loss in relief. 

Prior to this series, the White Sox lost all three against the Guardians, but did win two out of three against the Rays before that. Chicago has lost four games in a row and they are last in the AL Central standings. The Chicago pitching staff has a 4.21 ERA with a 1.36 WHIP and a .246 opponent batting average, while the offense has scored 601 runs with a .234 batting average and a .303 on base percentage this season. Lenyn Sosa has led Chicago with 20 home runs and 68 RBIs, while Andrew Benintendi has added 19 home runs and 60 RBIs this year. The projected starting pitcher for Chicago is Shane Smith, who is 6-7 with a 3.78 ERA and a 1.18 WHIP over 131.0 innings pitched this year. 

Why the White Sox will beat the Orioles 

The Orioles have lost seven of their last eight night games against American League opponents.
The home team has won five of the White Sox’s last six games.
The Orioles have failed to cover the run line each of their last nine Tuesday night games against teams that held a losing record.
The White Sox have covered the run line in eight of their last nine games against American League opponents that held a losing record.
The Orioles have lost the first inning in six of their last eight road games against opponents that held a losing record.

Total Runs Facts

Each of the White Sox’s last five games against American League opponents have gone UNDER the total runs line.
Each of the Orioles’ last four night games after playing the previous day have gone UNDER the total runs line.
The ‘Inning 1 OVER 0.5 runs’ market has hit in seven of the White Sox’s last eight home games.
The ‘Inning 1 OVER 0.5 runs’ market has hit in four of the Orioles’ last five games against AL Central opponents.

Chicago White Sox Player Prop Facts

Andrew Benintendi has hit at least one home run in three of his last nine appearances in night games.
Luis Robert has recorded at least one hit in each of his last seven home appearances against opponents that held a losing record.

Baltimore Orioles Player Prop Facts

Dean Kremer has recorded six or more strikeouts in each of his last three road appearances against AL opponents.
Ryan Mountcastle has recorded a Double in three of his last four road appearances against the White Sox after playing the previous day.
Ryan Mountcastle has recorded at least one hit in each of his last nine appearances against AL Central opponents.
Colton Cowser has hit a home run in each of the Orioles’ last two games.

Orioles vs White Sox Prediction

Chicago comes into this contest looking to snap their four game losing streak, but they have scored just four runs in those four games. The White Sox are 32-44 at home this year, while the Orioles are 34-42 on the road. Baltimore bounced back from getting swept this past weekend and they are starting Kremer, who has allowed 0, 7, 6, 0, and 1 earned run in his last five starts. Chicago is going with Smith, who has allowed two earned runs or fewer in three of his last four starts. Take the White Sox here.